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TIMP1 Mouse mAb, Cy3 conjugate

d(bsm-43009M-Cy3)-100ul
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  • bsm-43009M-Cy3
  • 2025年12月01日
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      100ul

    产品编号bsm-43009M-Cy3
    英文名称TIMP1 Mouse mAb, Cy3 conjugated
    中文名称Cy3标记的金属蛋白酶组织抑制因子-1单克隆抗体
    英文别名Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Mouse
    免疫原Recombinant human TIMP1 protein
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Monoclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > TIMPs

    Cancer > Invasion/microenvironment > ECM > Extracellular matrix > TIMPs

    Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > TIMP

    Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Metalloprotease inhibitors > TIMPs

    Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > TIMP1 / TIMP2

    亚细胞定位Secreted.
    翻译后修饰The activity of TIMP1 is dependent on the presence of disulfide bonds.
    相似性Belongs to the protease inhibitor I35 (TIMP) family.
    Contains 1 NTR domain.
    功能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq].

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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