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- bs-2097R-APC
- 2025年12月01日
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100ul
| 产品编号 | bs-2097R-APC |
| 英文名称 | Angiotensin II Type 1 Receptor Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的血管紧张素Ⅱ-1型受体抗体 |
| 英文别名 | AG2S; Agtr 1; Agtr1; Agtr1a; AGTR1B; Angiotensin II receptor type 1; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; AGTR1_HUMAN; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1R; Ang II; Angiotensin II receptor type 1; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT1; AT1R. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human AT1R |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Cellular metabolic process Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors Cardiovascular > Blood > Blood Pressure regulation Metabolism > Types of disease > Cancer |
| 亚基 | Interacts with MAS1 (Probable). Interacts with ARRB1. |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Liver, lung, adrenal and adrenocortical adenomas. |
| 翻译后修饰 | C-terminal Ser or Thr residues may be phosphorylated. |
| 相似性 | Belongs to the G-protein coupled receptor 1 family. |
| 功能 | Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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文献和实验Peptide-Conjugated Quantum Dots: Imaging the Angiotensin Type 1 Receptor in Living Cells
. These conjugates have been used to image angiotensin I-expressing Chinese hamster ovary (CHO) cells in vitro. When CHO cells were incubated with Ang II before incubating with Ang II-conjugated quantum dots, we were able to block the binding of the dots. The Ang II
Characterization of Angiotensin II Receptors
. Hypertension 25:924‐927. Feral, C., Benhaim, A., and Leymarie, P. 1996. Angiotensin II receptor type I on granulosa and thecal cells of rabbit preovulatory follicles. Biochim
II 受体type II 受体会吸引并磷酸化 type I 受体磷酸化后的 type I 受体吸引并磷酸化 regulated SMAD（R-SMAD）磷酸化后的 R-SMAD 会结合上 common SMAD（coSMAD、SMAD4）并形成异元二聚体（heterodimeric complex）该异元二聚体会进入细胞核中作为多种基因表现的转译因子，包括利用 8 种途径活化促分裂蛋白质激酶（mitogen-activated protein kinase）的产生，进而引发细胞凋亡。而 SMAD
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