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- Bioss
- bsm-43637R-APC-Cy5.5
- 2025年12月01日
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100ul
| 产品编号 | bsm-43637R-APC-Cy5.5 |
| 英文名称 | NGFR Recombinant Rabbit mAb, APC-Cy5.5 conjugated |
| 中文名称 | APC-Cy5.5标记的神经生长因子受体重组兔单抗 |
| 英文别名 | TNR16_HUMAN; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor(NGF receptor 1 Publication); p75 ICD; CD271; TNFRSF16; p75NTR; p75(NTR); Gp80-LNGFR; p75 NGF Receptor; |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 免疫原 | Recombinant human NGFR protein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Growth and Development > Neurotrophins Stem Cells > Mesenchymal Stem Cells > Surface Molecules Stem Cells > Neural Stem Cells > Surface Molecules |
| 亚基 | Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1 (By similarity). Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor. Interacts with NRADD. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 翻译后修饰 | N- and O-glycosylated.
Phosphorylated on serine residues. |
| 相似性 | Contains 1 death domain. Contains 4 TNFR-Cys repeats. |
| 功能 | Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells. NGF is important for the development, differentiation and survival of a variety of neuronal and non-neuronal cells. Its action is mediated by binding to two distinct receptors, the high affinity p140 and low affinity p75. p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5, and NT-6. p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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NGFR Recombinant Rabbit mAb, APC-Cy5.5 conjugated(bsm-43637R-APC-Cy5.5)-100ul
￥3200
