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- bsm-61228R-BF555
- 2025年12月01日
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100ul
| 产品编号 | bsm-61228R-BF555 |
| 英文名称 | Acetyl CoA carboxylase Recombinant Rabbit mAb, BF555 conjugated |
| 中文名称 | BF555标记的乙酰辅酶A羧化酶重组兔单抗 |
| 英文别名 | ACAC; ACACA; ACACB; ACC; ACC-alpha; ACC1; ACC2; ACCA; ACCB; Acetyl-CoA carboxylase 1; Biotin carboxylase. |
| 产品应用 | IF=1:100-500, Flow-Cyt=1:100-200 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human Acetyl CoA carboxylase |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins Cardiovascular > Lipids / Lipoproteins > Fatty Acids > Synthesis Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Metabolism > Pathways and Processes > Redox metabolism > Fatty acid oxidation Signal Transduction > Metabolism > Lipid metabolism Signal Transduction > Metabolism > Mitochondrial |
| 亚基 | Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver. |
| 翻译后修饰 | Phosphorylation on Ser-1263 is required for interaction with BRCA1. |
| 相似性 | Contains 1 ATP-grasp domain. Contains 1 biotin carboxylation domain. Contains 1 biotinyl-binding domain. Contains 1 carboxyltransferase domain. |
| 功能 | Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 背景资料 | ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Acetyl-CoA carboxylase (ACC) catalyzes the pivotal step of the fatty acid synthesis pathway. The 265 kDa ACCα (ACC1) is the predominant isoform found in liver, adipocytes, and mammary gland, while the 280 kDa ACCβ (ACC2) is the major isoform in skeletal muscle and heart. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
| {Flow-Cyt} | {1:100-200} |
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