CK10/Cytokeratin 10 Recombinan
t Rabbit mAb, PerCP-Cy5.5 conjugated(bsm-52052R-PerCP-Cy5.5)-100ul- ￥3200
- Bioss
- bsm-52052R-PerCP-Cy5.5
- 2025年12月01日
- 产品信息以Bioss网站为准
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100ul
| 产品编号 | bsm-52052R-PerCP-Cy5.5 |
| 英文名称 | CK10/Cytokeratin 10 Recombinant Rabbit mAb, PerCP-Cy5.5 conjugated |
| 中文名称 | PerCP-Cy5.5标记的细胞角蛋白10重组兔单抗 |
| 英文别名 | type I cytoskeletal 10; BCIE; BIE; CK 10; CK-10; ck10; Cytokeratin 10; Cytokeratin-10; Cytokeratin10; EHK; k10; K1C10_HUMAN; Keratin 10; Keratin; Keratin type i cytoskeletal 10; Keratin type I cytoskeletal 59 kDa; Keratin-10; Keratin10; kpp; Krt 10; KRT10; krt10; Keratin, type I cytoskeletal 10. |
| 产品应用 | IF=1:200-1000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human Cytokeratin 10 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Intermediate Filaments > Class I > Cytokeratins |
| 亚基 | Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Seen in all suprabasal cell layers including stratum corneum. |
| 相似性 | Belongs to the intermediate filament family. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Cytokeratin 10 is a heterotetramer of two type I and two type II keratins. Cytokeratin 10 is generally associated with keratin 1. It is seen in all suprabasal cell layers including stratum corneum. A number of alleles are known that mainly differ in the Gly-rich region (positions 490-560). Defects in cytokeratin 10 are a cause of epidermolytic hyperkeratosis (EHK), also known as bullous congenital ichthyosiform erythroderma (BCIE) or bullous erythroderma ichthyosiformis congenita of Brocq. EHK is an hereditary skin disorder characterized by blistering and a marked thickening of the stratum corneum. At birth, affected individuals usually present with redness, blisters and superficial erosions due to cytolysis. Within a few weeks, the erythroderma and blister formation diminish and hyperkeratoses develop. Transmission is autosomal dominant, but most cases are sporadic. Defects in cytokeratin 10 are also a cause of annular epidermolytic ichthyosis (AEI), also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI resembles clinical and histologic features of both epidermolytic hyperkeratosis and ichthyosis bullosa of Siemens. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:200-1000} |
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CK10/Cytokeratin 10 Recombinant Rabbit mAb, PerCP-Cy5.5 conjugated(bsm-52052R-PerCP-Cy5.5)-100ul
￥3200
