Cadherin-1 Rabbit pAb, HRP conjugated(bs-42419R-HRP)-100ul

Cadherin-1 Rabbit pAb, HRP con

jugated(bs-42419R-HRP)-100ul
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  • ￥2980
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  • bs-42419R-HRP
  • 2025年12月01日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-42419R-HRP
    英文名称Cadherin-1 Rabbit pAb, HRP conjugated
    中文名称HRP标记的上皮钙粘附分子抗体
    英文别名CDH1; CADH1_HUMAN; CAM 120/80; Epithelial cadherin; Uvomorulin; CD324; CDHE, UVO .
    产品应用IHC-P=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原Recombinant human E cadherin protein
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Invasion/microenvironment > ECM > Cell adhesion > Cadherins

    Developmental Biology > Organogenesis > Excretory system development > Kidney development

    Signal Transduction > Antibodies > e cadherin

    Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Cadherins

    Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Binding Proteins

    亚基Homodimer.
    亚细胞定位Cell junction. Cell membrane; Single-pass type I membrane protein.
    组织特异性Non-neural epithelial tissues.
    翻译后修饰During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disaaaembly of adherens junctions.
    相似性Contains 5 cadherin domains.
    功能Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}

     

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