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- bsm-52250R-BF750
- 2025年12月01日
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100ul
| 产品编号 | bsm-52250R-BF750 |
| 英文名称 | HMGB1 Recombinant Rabbit mAb, BF750 conjugated |
| 中文名称 | BF750标记的高迁移率族蛋白B1重组兔单抗 |
| 英文别名 | High mobility group protein B1; Amphoterin; High mobility group 1; High Mobility Group Box 1; High mobility group protein 1; HMG3; HMGB 1; HMGB-1; Hmgb1 protein; Nonhistone chromosomal protein HMG1; SBP 1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; HMGB1_HUMAN. |
| 产品应用 | IF=1:200-1000, ICC/IF=1:100-500, Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human HMGB1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Histones > HMGs Epigenetics and Nuclear Signaling > Transcription > Domain Families > HMG Box Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Signal Transduction > Antibodies > hmgb1 |
| 亚基 | Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. |
| 亚细胞定位 | Nucleus. Chromosome. |
| 相似性 | Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains. |
| 功能 | DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve dependent mechanism, inhibits HMGB1 release in experimental disease models |
| 应用 | 推荐稀释比例 |
| {IF} | {1:200-1000} |
| {ICC/IF} | {1:100-500} |
| {Flow-Cyt} | {1μg/Test} |
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HMGB1 Recombinant Rabbit mAb, BF750 conjugated(bsm-52250R-BF750)-100ul
￥3200
