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- bsm-52565R-IRDye800CW
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100ul
| 产品编号 | bsm-52565R-IRDye800CW |
| 英文名称 | GAP43 Recombinant Rabbit mAb, IRDye 800CW conjugated |
| 中文名称 | IRDye 800CW标记的神经生长相关蛋白43重组兔单克隆抗体 |
| 英文别名 | Growth Associated Protein-43; Neuromodulin; Axonal membrane protein GAP 43; B-50; F1; GAP 43; Growth Associated Protein 43; Nerve Growth Related Peptide; Neural phosphoprotein B 50; Neuromodulin; GAP-43; pp46; NEUM_HUMAN; Protein F1; QtrA-11580; QtrA-13071. |
| 产品应用 | WB=1:1000-5000, IP=1:20-100 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human GAP43 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 浓度 | 1mg/ml |
| 储存液 | PBS, Glycerol, BSA. |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Growth Cone Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins |
| 亚基 | Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. |
| 亚细胞定位 | Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, growth cone membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell projection, filopodium membrane; Peripheral membrane protein. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. |
| 翻译后修饰 | Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.
Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2. |
| 相似性 | Belongs to the neuromodulin family. Contains 1 IQ domain. |
| 功能 | This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:1000-5000} |
| {IP} | {1:20-100} |
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文献和实验Site‐Specific Protein Labeling with SNAP‐Tags
Materials BG‐800 [synthesized from BG‐NH 2 (Toronto Research Chemicals, cat no. A614425; http://www.trc‐canada.com/) and IRDye 800CW NHS (LI‐COR Biosciences, http://www
secondary antibody review -- data from 99 publications
data
Measurement of Oxygen Radicals and Lipid Peroxidation in Neural Tissues
and 3‐NT IRDye800CW goat anti‐rabbit IgG (Rockland Immunochemicals, cat. no. 611‐131‐122) 1.5‐ or 2.0‐ml centrifuge tubes
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