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- bsm-52466R-PerCP-Cy7
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100ul
| 产品编号 | bsm-52466R-PerCP-Cy7 |
| 英文名称 | ICAM1 Recombinant Rabbit mAb, PerCP-Cy7 conjugated |
| 中文名称 | PerCP-Cy7标记的细胞间粘附分子-1（CD54）重组兔单抗 |
| 英文别名 | BB2; CD54 antigen; ICAM 1; ICAM-1; Cell surface glycoprotein P3.58; Human rhinovirus receptor; Intercellular adhesion molecule 1; Major group rhinovirus receptor; MALA2; MyD10; P3.58; Surface antigen of activated B cells; ICAM1_HUMAN; MALA-2; MyD10; intercellular adhesion molecule 1 precursor; intercellular adhesion molecule 1(CD54), human rhinovirus receptor; major group rhinovirus receptor. |
| 产品应用 | IF=1:50-200 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human ICAM 1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Angiogenesis > Endothelial Cell Markers Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Cell adhesion molecules Immunology > Adaptive Immunity > Regulatory T Cells Immunology > Cell Type Markers > CD > Adhesion Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Stem Cells > Hematopoietic Progenitors > Lymphoid > B Lymphocytic Lineage Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage |
| 亚基 | Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 翻译后修饰 | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| 相似性 | Belongs to the immunoglobulin superfamily. ICAM family. ontains 5 Ig-like C2-type (immunoglobulin-like) domains. |
| 功能 | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:50-200} |
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ICAM1 Recombinant Rabbit mAb, PerCP-Cy7 conjugated(bsm-52466R-PerCP-Cy7)-100ul
￥2980
