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- bsm-61660R-PerCP-Cy7
- 2025年12月01日
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100ul
| 产品编号 | bsm-61660R-PerCP-Cy7 |
| 英文名称 | IFIH1 Recombinant Rabbit mAb, PerCP-Cy7 conjugated |
| 中文名称 | PerCP-Cy7标记的黑色素瘤分化相关蛋白5重组兔单抗 |
| 英文别名 | Helicard; Hlcd; IDDM19; IFIH1; MDA-5; RH116; RIG I like receptor 2; RLR 2; RNA helicase DEAD box protein 116. |
| 产品应用 | ICC/IF=1:50-200 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human MDA5 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Immunology > Immune System Diseases > Antiviral Signaling Immunology > Innate Immunity > Cytokines > Interferons Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚细胞定位 | Cytoplasm. Nucleus. May be found in the nucleus, during apoptosis. |
| 组织特异性 | Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. |
| 翻译后修饰 | During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation. |
| 相似性 | Belongs to the helicase family. Contains 2 CARD domains. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
| 功能 | RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific RNases. Seems to have growth suppressive properties. Involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). ATPase activity is specifically induced by dsRNA. Essential for the production of interferons in response to picornaviruses. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
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IFIH1 Recombinant Rabbit mAb, PerCP-Cy7 conjugated(bsm-61660R-PerCP-Cy7)-100ul
￥2980
