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文献和实验Aspects of CNS Lupus: Mouse Models of Anti-NMDA Receptor Antibody Mediated Reactivity
This chapter describes methods utilized in establishing a mouse model of neuropsychiatric lupus encompassing both cognitive and emotional dysfunction, and a model of the influence of maternal antibody on the developing brain. The antibody
This work describes protocols for the production of single-chain antibody and T-cell receptor fragments inE. coli . A choice of methods is given for the purification of the recombinant fragments that rely on the use of either immunoaffinity
Antibody Targeted siRNA Delivery
only. The commercial success of in vivo applications of RNAi hinges on the development of new delivery methods. Our strategy involves the use of antibody-based delivery agents to target and deliver siRNA into specific cell types. We have developed antibody-based agents
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