促甲状腺素受体抗体（N端）

促甲状腺素受体抗体（N端）产品介绍

TSHR是垂体前叶嗜碱细胞分泌的一种糖蛋白，直接作用于甲状腺，并能影响其结构功能。该抗体主要用于垂体肿瘤功能性分类的研究。
The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligandszk-12581R phospho-beta Actin (Tyr53)磷酸化β-肌动蛋白抗体
zk-12978R phospho-beta 2 Adrenergic Receptor (Ser346)磷酸化肾 上 腺 素能受体β2/β2-AR 抗体
zk-12979R phospho-beta 2 Adrenergic Receptor (Ser355 + Ser356)磷酸化肾 上 腺 素能受体β2/β2-AR抗体
zk-10130R APOD载脂蛋白D抗体
zk-2586R ASIC1/BNaC2/ASIC1A酸敏感离子通道1抗体
zk-2168R ADAR1 (C-terminus)双链RNA腺苷酸脱氨基酶抗体（C端）
zk-3696R AF10髓系、淋巴、混合系白血病易位基因10抗体
zk-3681R ADCY1腺苷酸环化酶1抗体
zk-3680R APC腺瘤样息肉抗体
zk-5023R AGPAT1溶血磷脂酰基转移酶抗体
zk-9098R ANKS3锚蛋白重复及SAM结构域蛋白3抗体
zk-3047R phospho-ALK (Tyr1586)磷酸化间变型淋巴瘤激酶抗体
zk-5018R ACADVL酰基辅酶A脱氢酶很长链抗体
zk-7735R AMSH信号转导衔接结合蛋白抗体
zk-7736R ASB3锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族3抗体
zk-2750R Aurora C有丝分裂激酶B抗体
zk-3045R Phospho-Ack1 (Tyr284)磷酸化Ack1抗体
zk-3046R Phospho-Ack1 (Tyr326)磷酸化Ack1抗体
zk-3048R Phospho-beta-Arrestin 1 (Ser412)磷酸化β抑制蛋白1抗体
zk-3050R Phospho-Aurora A (Thr288)磷酸化有丝分裂激酶A抗体
zk-3003R phospho-APS(Ser598)磷酸化APS抗体
zk-2749R Aurora A有丝分裂激酶A抗体
zk-5986R AIM2干扰素诱导蛋白AIM2抗体
zk-4611R Aquaporine 2水通道蛋白-2抗体
zk-5984R ABI2肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白抗体
zk-5987R ARL11ADP核糖基化因子样11抗体
促甲状腺素受体抗体（N端）