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- 克隆性：
单克隆
- 抗体英文名：
Anti-CKⅡα/STK(Casein
- 抗体名：
属丝/苏氨酸蛋白质激酶抗体
属丝/苏氨酸蛋白质激酶抗体产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
属丝/苏氨酸蛋白质激酶抗体产品介绍
STKII参与调节细胞周期阻滞、细胞生长、细胞凋亡.在细胞形态学和动力学以及细胞转化的调控方面起到了很重要的作用。
[FUNCTION] IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
[CATALYTIC ACTIVITY] ATP + a protein = ADP + a phosphoprotein.
[ENZYME REGULATION] Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity).
[SUBUNIT] Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.
[INTERACTION] Q16543:CDC37; NbExp=1; IntAct=EBI-296115, EBI-295634.
[SUBCELLULAR LOCATION] Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PKB gamma; IsoId=Q9Y243-1; Sequence=Displayed; Name=2; Synonyms=PKB gamma 1; IsoId=Q9Y243-2; Sequence=VSP_004947.
[TISSUE SPECIFICITY] In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
[DOMAIN] Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
[PTM] Phosphorylated upon DNA damage, probably by ATM or ATR. [SIMILARITY] Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
[SIMILARITY] Contains 1 AGC-kinase C-terminal domain.
[SIMILARITY] Contains 1 PH domain.
[SIMILARITY] Contains 1 protein kinase domain.
[WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematologyzk-0063R Calcitonin降钙素抗体
zk-15094R C20orf1420号染色体开放阅读框14抗体
zk-0743R CTGF结缔组织生长因子抗体
zk-1179R CTLA4细胞毒性T细胞抗原-4抗体
zk-0124R Calcitonin receptor降钙素受体抗体
zk-15065R C1orf381号染色体开放阅读框38抗体
zk-0727R CXorf36脱羧酶蛋白体36抗体
zk-1050R Connexin-40间隙连接蛋白40抗体
zk-0651R Connexin 43间隙连接蛋白43抗体
zk-0652R Connexin-45间隙连接蛋白45抗体
zk-1009R CXCR1细胞表面趋化因子受体1抗体
zk-0461R CYP450细胞色素P450单氧化酶抗体
zk-0013R Cytochrome C细胞色素C抗体
zk-1244R CK1细胞角蛋白1抗体
zk-0271R Cytomegalovirus pp65 巨细胞病毒PP65/CMV低基质磷脂蛋白抗体
zk-0282R Cyclin C周期素C抗体
zk-0572R Cyclin B1周期素B1抗体
zk-0590R Cytoglobin细胞球蛋白抗体
zk-0623R Cyclin D1周期素D1抗体
zk-1148R Cyclin D2周期素D2抗体
zk-0573R Cyclin E周期素E抗体
zk-2521R CD94/KLRD1NK细胞表面抑制性受体CD94抗体
zk-2498R CD58淋巴细胞功能相关抗原-3抗体
zk-2484R CCL27/CTACK皮肤T细胞虏获趋化因子抗体
zk-4872R Complement C3补体C3a过敏毒素抗体
zk-2477R Macrophage Inflammatory Protein 1 gamma巨噬细胞炎症蛋白-1γ抗体
zk-1996R CD171神经细胞粘附分子配体1抗体
zk-15284R C8orf30A8号染色体开放阅读框30a抗体
zk-3608R CYP11A1细胞色素P450 11A1抗体
zk-2047R CPT1A肉毒碱棕榈酰基转移酶1A抗体
属丝/苏氨酸蛋白质激酶抗体
[FUNCTION] IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
[CATALYTIC ACTIVITY] ATP + a protein = ADP + a phosphoprotein.
[ENZYME REGULATION] Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity).
[SUBUNIT] Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.
[INTERACTION] Q16543:CDC37; NbExp=1; IntAct=EBI-296115, EBI-295634.
[SUBCELLULAR LOCATION] Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PKB gamma; IsoId=Q9Y243-1; Sequence=Displayed; Name=2; Synonyms=PKB gamma 1; IsoId=Q9Y243-2; Sequence=VSP_004947.
[TISSUE SPECIFICITY] In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
[DOMAIN] Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
[PTM] Phosphorylated upon DNA damage, probably by ATM or ATR. [SIMILARITY] Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
[SIMILARITY] Contains 1 AGC-kinase C-terminal domain.
[SIMILARITY] Contains 1 PH domain.
[SIMILARITY] Contains 1 protein kinase domain.
[WEB RESOURCE] Name=Atlas of Genetics and Cytogenetics in Oncology and Haematologyzk-0063R Calcitonin降钙素抗体
zk-15094R C20orf1420号染色体开放阅读框14抗体
zk-0743R CTGF结缔组织生长因子抗体
zk-1179R CTLA4细胞毒性T细胞抗原-4抗体
zk-0124R Calcitonin receptor降钙素受体抗体
zk-15065R C1orf381号染色体开放阅读框38抗体
zk-0727R CXorf36脱羧酶蛋白体36抗体
zk-1050R Connexin-40间隙连接蛋白40抗体
zk-0651R Connexin 43间隙连接蛋白43抗体
zk-0652R Connexin-45间隙连接蛋白45抗体
zk-1009R CXCR1细胞表面趋化因子受体1抗体
zk-0461R CYP450细胞色素P450单氧化酶抗体
zk-0013R Cytochrome C细胞色素C抗体
zk-1244R CK1细胞角蛋白1抗体
zk-0271R Cytomegalovirus pp65 巨细胞病毒PP65/CMV低基质磷脂蛋白抗体
zk-0282R Cyclin C周期素C抗体
zk-0572R Cyclin B1周期素B1抗体
zk-0590R Cytoglobin细胞球蛋白抗体
zk-0623R Cyclin D1周期素D1抗体
zk-1148R Cyclin D2周期素D2抗体
zk-0573R Cyclin E周期素E抗体
zk-2521R CD94/KLRD1NK细胞表面抑制性受体CD94抗体
zk-2498R CD58淋巴细胞功能相关抗原-3抗体
zk-2484R CCL27/CTACK皮肤T细胞虏获趋化因子抗体
zk-4872R Complement C3补体C3a过敏毒素抗体
zk-2477R Macrophage Inflammatory Protein 1 gamma巨噬细胞炎症蛋白-1γ抗体
zk-1996R CD171神经细胞粘附分子配体1抗体
zk-15284R C8orf30A8号染色体开放阅读框30a抗体
zk-3608R CYP11A1细胞色素P450 11A1抗体
zk-2047R CPT1A肉毒碱棕榈酰基转移酶1A抗体
属丝/苏氨酸蛋白质激酶抗体
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文献和实验相关实验
酶(calcineurin)属丝／苏氨酸磷酸酶，其底物是转录因子NF-AT分子已发生磷酸化的丝氨酸和苏氨酸残基。在钙调磷酸酶的作用下，NF-ATp因脱去磷酸根(p)而激活，成为活化的转录因子NF-AT。
1. 前言 蛋白质翻译后磷酸化修饰是影响真核细胞每一个细胞内活动过程的最丰富的细胞调节形式。一个蛋白质的磷酸化能引起结构、稳定性、酶活，与其他分子之间相互作用的能力或其亚细胞定位的改变。蛋白激酶催化可逆的蛋白质底物的磷酸化，作用在其丝氨 酸、苏氨酸和酪氨酸残基位点上。如在拟南芥中，丝氨酸/苏氨酸激酶占整个蛋白质组 的 4% [1] ，但对它们的生物学功能还不十分了解。因此，我们需要能开展蛋白激酶全球分析的高通量蛋白质组学方法[ 2，3] 来鉴定下游底物。 用于确定磷酸化共有
的研究已经成为蛋白质科学的热点之一。 磷酸化多肽（主要指肽链中的酪氨酸、丝氨酸和苏氨酸残基的侧链羟基被磷酸化生成酸式磷酸酯的修饰多肽）是研究蛋白质磷酸化过程的必不可少的工具，它可作为磷酸酶模型底物，或作为可产生抗磷酸化蛋白抗体的抗原，也可以在确定磷酸化蛋白的物理参数时作为参考化合物等[3]。因此磷酸化多肽的合成在过去的几年中吸引了相当大的兴趣，目前已确定了较为成熟的合成路线，使磷酸化多肽的合成趋于常规。目前磷酸化多肽的合成主要有两个策略：后磷酸化法（Global
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属丝/苏氨酸蛋白质激酶抗体
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