属丝/苏氨酸蛋白质激酶抗体

属丝/苏氨酸蛋白质激酶抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

属丝/苏氨酸蛋白质激酶抗体产品介绍

STKII参与调节细胞周期阻滞、细胞生长、细胞凋亡.在细胞形态学和动力学以及细胞转化的调控方面起到了很重要的作用。
[FUNCTION] IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
[CATALYTIC ACTIVITY] ATP + a protein = ADP + a phosphoprotein.
[ENZYME REGULATION] Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity).
[SUBUNIT] Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.
[INTERACTION] Q16543:CDC37; NbExp=1; IntAct=EBI-296115, EBI-295634.
[SUBCELLULAR LOCATION] Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PKB gamma; IsoId=Q9Y243-1; Sequence=Displayed; Name=2; Synonyms=PKB gamma 1; IsoId=Q9Y243-2; Sequence=VSP_004947.
[TISSUE SPECIFICITY] In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
[DOMAIN] Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
[PTM] Phosphorylated upon DNA damage, probably by ATM or ATR. [SIMILARITY] Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
[SIMILARITY] Contains 1 AGC-kinase C-terminal domain.
[SIMILARITY] Contains 1 PH domain.
[SIMILARITY] Contains 1 protein kinase domain.
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属丝/苏氨酸蛋白质激酶抗体