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- 详细信息
- 技术资料
- 克隆性：
单克隆
- 抗体英文名：
Anti-PTP-1B(Protein
- 抗体名：
蛋白酪氨酸磷酸酶-1B
蛋白酪氨酸磷酸酶-1B产品标准
浓缩液(1mg/1ml) 亲和纯化抗体
产品应用
WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）
蛋白酪氨酸磷酸酶-1B产品介绍
激酶和磷酸酶（Kinases and Phosphatases）
P-tyr蛋白酪氨酸磷酸酶1B（PTP1B）是一种胰岛素信号的负性调节因子，与肥胖症和2型糖尿病的发病及发展关系密切。对P-tyr基因敲除小鼠的研究表明，缺失PTP1B小鼠的胰岛素敏感性明显增加，并对肥胖有一定的抵抗作用，而另一些对动物和人体的研究结果却与此相反，发现PTP1B可通过引起胰岛素抵抗、瘦素抵抗及影响脂代谢等而导致肥胖症和2型糖尿病的发生。一些特异性的Ptyr小分子抑制剂已经开发并用于肥胖和糖尿病的治疗中。
PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and is a drug discovery target in the fields of diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.
PTP1B also interacts with Insulin and EGF receptors, and undergoes phosphorylation after receptor stimulation. Tyrosine phosphorylation at Tyr-66, Tyr-152, and Tyr-153 occurs after insulin receptor activation, and tyrosine phosphorylation of Tyr-152 may be required for interactions with N-Cadherin. In addition, Akt can phosphorylate Ser-50 and this phosphorylation can reduce PTP1B activity.
mol wt:49kDa
Other Aliases:
Non receptor tyrosine phosphatase 1; Protein tyrosine phosphatase 1B; Protein tyrosine phosphatase non receptor type 1; Protein tyrosine phosphatase placental; PTP 1B; PTPN 1; PTPN1; Tyrosine protein phosphatase non receptor type 1zk-1747R DRD5多巴胺受体D5抗体
zk-1721R dUTPase脱氧尿嘧啶三磷酸核苷水解酶抗体
zk-1743R DRD3多巴胺受体D3抗体
zk-1716R DcR3诱捕受体3抗体
zk-1714R DAT多巴胺转运蛋白DAT抗体
zk-1694R DcR2诱捕受体2抗体
zk-1696R DR5肿瘤细胞调亡素/死亡受体5抗体
zk-1695R DCN/Decorin 核心蛋白聚糖抗体
zk-7609R DUSP2双特异性磷酸酶2抗体
zk-9312R C21orf10621号染色体开放阅读框106抗体
zk-6974R Dlx5同源转录因子DLX5抗体
zk-9467R DVL3DVL3蛋白抗体
zk-1359R DNA PKcsDNA依赖蛋白激酶催化亚基抗体
zk-1361R DDIT3GADD153抗体
zk-8555R Desmuslin中间丝蛋白β-synemin抗体
zk-9669R DENND4CMAP激酶激活死亡域蛋白4C抗体
zk-9926R Desmocollin 4桥粒糖蛋白4抗体
zk-11343R Dynamin 3酶动力蛋白3抗体
zk-7000R Delta Cateninδ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体
zk-11066R DOK6胞浆接头蛋白Dok6抗体
zk-8587R DOK5胞浆接头蛋白Dok5抗体
zk-9394R DCAF12睾丸癌中心体相关蛋白抗体
zk-9395R DCAF13DCAF13蛋白抗体
zk-6999R DCHS1原钙粘蛋白16抗体
zk-6998R ERR-alpha雌激素受体相关蛋白α抗体
zk-8291R DPY19L2DPY19L2蛋白抗体
蛋白酪氨酸磷酸酶-1B
P-tyr蛋白酪氨酸磷酸酶1B（PTP1B）是一种胰岛素信号的负性调节因子，与肥胖症和2型糖尿病的发病及发展关系密切。对P-tyr基因敲除小鼠的研究表明，缺失PTP1B小鼠的胰岛素敏感性明显增加，并对肥胖有一定的抵抗作用，而另一些对动物和人体的研究结果却与此相反，发现PTP1B可通过引起胰岛素抵抗、瘦素抵抗及影响脂代谢等而导致肥胖症和2型糖尿病的发生。一些特异性的Ptyr小分子抑制剂已经开发并用于肥胖和糖尿病的治疗中。
PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and is a drug discovery target in the fields of diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.
PTP1B also interacts with Insulin and EGF receptors, and undergoes phosphorylation after receptor stimulation. Tyrosine phosphorylation at Tyr-66, Tyr-152, and Tyr-153 occurs after insulin receptor activation, and tyrosine phosphorylation of Tyr-152 may be required for interactions with N-Cadherin. In addition, Akt can phosphorylate Ser-50 and this phosphorylation can reduce PTP1B activity.
mol wt:49kDa
Other Aliases:
Non receptor tyrosine phosphatase 1; Protein tyrosine phosphatase 1B; Protein tyrosine phosphatase non receptor type 1; Protein tyrosine phosphatase placental; PTP 1B; PTPN 1; PTPN1; Tyrosine protein phosphatase non receptor type 1zk-1747R DRD5多巴胺受体D5抗体
zk-1721R dUTPase脱氧尿嘧啶三磷酸核苷水解酶抗体
zk-1743R DRD3多巴胺受体D3抗体
zk-1716R DcR3诱捕受体3抗体
zk-1714R DAT多巴胺转运蛋白DAT抗体
zk-1694R DcR2诱捕受体2抗体
zk-1696R DR5肿瘤细胞调亡素/死亡受体5抗体
zk-1695R DCN/Decorin 核心蛋白聚糖抗体
zk-7609R DUSP2双特异性磷酸酶2抗体
zk-9312R C21orf10621号染色体开放阅读框106抗体
zk-6974R Dlx5同源转录因子DLX5抗体
zk-9467R DVL3DVL3蛋白抗体
zk-1359R DNA PKcsDNA依赖蛋白激酶催化亚基抗体
zk-1361R DDIT3GADD153抗体
zk-8555R Desmuslin中间丝蛋白β-synemin抗体
zk-9669R DENND4CMAP激酶激活死亡域蛋白4C抗体
zk-9926R Desmocollin 4桥粒糖蛋白4抗体
zk-11343R Dynamin 3酶动力蛋白3抗体
zk-7000R Delta Cateninδ连环蛋白/δ连环素/δ链接素（δ-catenin）抗体
zk-11066R DOK6胞浆接头蛋白Dok6抗体
zk-8587R DOK5胞浆接头蛋白Dok5抗体
zk-9394R DCAF12睾丸癌中心体相关蛋白抗体
zk-9395R DCAF13DCAF13蛋白抗体
zk-6999R DCHS1原钙粘蛋白16抗体
zk-6998R ERR-alpha雌激素受体相关蛋白α抗体
zk-8291R DPY19L2DPY19L2蛋白抗体
蛋白酪氨酸磷酸酶-1B
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蛋白酪氨酸磷酸酶-1B
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