Mouse TNFSF11/RANKL ELISA Kit

Mouse TNFSF11/RANKL ELISA Kit

Catalog No.: IRKTAH5466

$495
Category: Assay and ELISA Kits

Product Description

Mouse TNFSF11/RANKL ELISA Kit - 1 Kit (96 Wells)

Our Mouse TNFSF11/RANKL ELISA Kit is a sandwich ELISA intended for the quantitative determination of mouse TNFSF11 in cell culture supernates, serum and plasma (heparin, EDTA).

Receptor activator of nuclear factor kappa-B ligand(RANKL), also known as tumor necrosis factor ligand superfamily member 11(TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor(TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

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