- 询价
- R&D
- ZK-0101967
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
1 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- GABAA Receptor α1 Subunit Polyclonal Antibody详细信息：
-
Description Polyclonal Antibody against GABAA α1-Subunit Form Antiserum Host Rabbit Species Reactivity Rat. Bovine, human, mouse, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. Specificity GABAA Receptor α1 Subunit Polyclonal AntibodyGamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α and β subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a γ subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α subunits of the receptor. Lastly, phosphorylation of β subunits of the receptor has been shown to modulate GABAA-R function.
This antibody was raised against a peptide representing a sequence that is specific for the α1 subunit of the receptor. It recognizes a 51k band in Western blots of rat brain. The peptide antigen has no homology with any other GABAA-R subunit. Bovine, human, mouse, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody.Uses This antibody is effective in immunoblotting; other applications not yet determined. Suggested Working Dilution GABAA Receptor α1 Subunit Polyclonal AntibodyThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000*
- Dot blot: 1:1,000
Notes *Predicted MW = 51kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Long term storage should be at -80°C. This shelf-life of this product is approximately 1 year.
References Kittler JT, McAinsh K, Moss SJ. Mechanisms of GABA A receptor assembly and trafficking - Implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26:2251 - 268, 2002.
Whiting PJ, McKernan RM, Wafford KA. Structure and pharmacology of vertebrate, GABAA receptor subtypes. In: International Review of Neurobiology (Bradley RJ, Harris RA, eds.), pp 95, San Diego: Academic Press, 1995.
Olsen RW, Tobin AJ. Molecular biology of GABAA receptors. FASEB 4:1469 - 1480, 1990.
Pritchett DB, Sontheimer H, Shivers BD, Yner S, Kettenman H, Schofield PR, Seeburg PH. Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology.Nature (London) 338:582-585, 1989.
Blair LAC, Levitan ES, Marshall J, Dionne VE, Barnard EA. Single subunits of the GABAA receptor form ion channels with properties of the native receptor. Science 242:577-579, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - GABAA Receptor α1 Subunit Polyclonal Antibody
- zk-1277zk CFTR(cystic fibrosis transmembrane conductance regulator)囊性纤维化跨膜转运调节因子抗原
zk-0775zk CG6856-PA peptideCG6856-PA抗原
zk-0539zk CGA(Chromogranin A)嗜铬粒素A抗原
zk-0543zk CGB(Chromogranin B)嗜铬粒素B抗原
zk-1150zk ChRM1(muscarinic acetylcholine receptor)毒蕈碱型乙酰胆碱受体M1抗原
zk-1289zk ChRM3 peptide毒蕈碱型乙酰胆碱受体M3抗原
zk-1059zk CK18(Cytokeratin 18)细胞角蛋白18(多肽)
zk-2043zk CK18 peptide细胞角蛋白18多肽抗原
zk-1339zk CK18(Cytokeratin 18)细胞角蛋白18抗原（C端）
zk-1792zk CK14/17/42/10 peptide细胞角蛋白14抗原
zk-1270zk CK16(Cytokeratin 16)细胞角蛋白16抗原
zk-1431zk CK17(Cytokeratin 17)细胞角蛋白17抗原
zk-1244zk CK1/8/19 (Cytokeratin1/8/19; Keratin 1/8/19)peptide细胞角蛋白1/8/19抗原
zk-1005zk CK2(casein kinase 2)细胞角蛋白2抗原
zk-1060zk CK5(Cytokeratin 5)细胞角蛋白5抗原
zk-1610zk CK7(Cytokeratin 7)human细胞角蛋白7抗原
zk-1106zk CK8(Cytokeratin 8)细胞角蛋白8（多肽）
zk-1330zk CKIP-1(casein kinase 2 interaction protein 1)酪蛋白激酶2相互作用蛋白1抗原
zk-1585zk CLCA4(Calcium-activated chloride channel 4)钙激活氯离子通道4抗原
zk-0548zk C-Mer/MERTK (proto-oncogene tyrosine kinase)c-mer原癌基因酪氨酸激酶抗原
zk-0842zk c-Myc tag c-Myc tag标签多肽
zk-2113zk AU5 tagAU5 tag标签抗原
zk-2114zk AU1 tag peptideAU1 tag标签多肽
zk-2115zk Glu-Glu Tag peptideGlu-Glu Tag多肽蛋白
zk-2074zk CNGA2(Cyclic Nucleotide Gated Cation Alpha 2)环核苷酸阳离子通道蛋白α2抗原
zk-1000zk CNP/CNPase ( 2',3'-cyclic-nucleotide 3'-phosphodiesterase)C型钠尿肽抗原
zk-1272zk CNTF(Ciliary Neurotrophic Factor)睫状神经营养因子抗原
zk-1040zk factor V(Vcoagulation factor)凝血因子5抗体
zk-0549zk Collagen III (Anti-Collagen Type III )抗Ⅲ型胶原抗原(Collagen Ⅲ Ⅲ型胶原)
zk-0948zk Collagen III (Anti--Collagen Type III )Ⅲ型胶原抗原(Collagen Ⅲ Ⅲ型胶原)
zk-0806zk Collagen IVIV型胶原(Collagen Ⅳ Ⅳ 型胶原)
zk-0578zk Collagen I(Anti-Collagen Type I)I型胶原蛋白
zk-0552zk Collagen V (Anti--Collagen Type V )Ⅴ型胶原(多肽)
zk-1428zk CLDN1(Claudin 1)紧密连接蛋白1抗原
zk-2183zk Claudin-11 peptide少突胶质细胞跨膜蛋白抗原
zk-0790zk CLDN1(Claudin 1)C-term紧密连接蛋白1抗原(C端)
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
GABAA Receptor α1 Subunit Polyclonal Antibody
询价
