- 询价
- R&D
- ZK-0101516
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody (SIGNET)保存于运输说明：
- Store at -20°C or below.
- 详细信息：
-
Description Beta Amyloid (Aβ) Monoclonal Antibody, 4G8
(Formerly Signet Catalog Nos.: 9200-02, 9200-05, 9200-10)
Covance is the Exclusive Provider of this Antibody ProductIntended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 4G8 Form Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody (SIGNET)Ascites Fluid Host Mouse Species Reactivity Human, Mouse IsoType IgG2b [Ab] ~2 mg/mL Specificity This antibody is reactive to amino acid residues 17-24 of beta amyloid. The epitope lies within amino acids 18-22 of beta Amyloid (VFFAE). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Signet’s beta Amyloid antibody 4G8 reacts to the abnormally processed isoforms, as well as precursor forms. Uses This antibody is effective in immunoblotting, immunohistochemistry (IHC), immunoprecipitation (IP) immunoaffinity purifications and ELISA. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - IHC: 1:100 - 1:1,000
Tissue Sections: Formalin-fixed human and animal paraffin-embedded brain sections
Pretreatment: Formic acid (70%) for 10-30 minutes at room temperature
- ELISA: 1:1,000 - 1:10,000
Storage Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody (SIGNET)Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.
Kimura N, et al. Age-related changes of intracellular Abeta in cynomolgus monkey brains. Neuropath Appl Neurobiol 31(2):170-80, 2005.
Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11(5):556-61, 2005.
Iijima K, et al. Dissecting pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer’s disease. PNAS 101(17):6623-6628, 2004.
Li M, et al. Macrophage colony stimulatory factor and interferon-gamma trigger distinct mechanisms for augmentation of beta-amyloid-induced microgliamediated neurotoxicity. J Neurochem 91:623-33, 2004.
Poduloso JF, et al. Design and chemical synthesis of a magnetic resonance contrast agent with enhanced in vitro binding, high blood-brain barrier permeability, and in vivo targeting to Alzheimer’s disease amyloid plaques. Biochem 43:6064-6075, 2004.
Venezia V, et al. Apoptotic cell death influences the signaling activity of the amyloid precursor protein through SchA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells. J Neurochem 90:1359-1370, 2004.
Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci Res Comm 2:121-130, 1988.
Kim KS, et al. Neurosci Res Comm 7:113, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - IHC: 1:100 - 1:1,000
- Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody (SIGNET)
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Beta-Amyloid, 17-24 (4G8) Monoclonal Antibody (SIGNET)
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