- 询价
- R&D
- ZK-0101200
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Neurofilament α-Internexin/NF66 Monoclonal Antibody保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description Monoclonal Antibody aganist Neurofilament α-Internexin/NF66 Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 2E3 Form Tissue Culture Supernatant Host Neurofilament α-Internexin/NF66 Monoclonal AntibodyMouse Species Reactivity Mammalian IsoType IgG1 Specificity α-internexin is a ~66 kDa Class IV intermediate filament. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain α-internexin in addition to NF-L, NF-M anbd NF-H. In some mature neurons α-internexin is the only neurofilament subunit expressed. Antibodies to α-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of α-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. In addition recent studies show a marked up-regulation of α-internexin during neuronal regeneration. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
MCA-2E3 was raised against recombinant rat α-internexin expressed in and purified from E. coli. It reacts with human α-internexin and with this protein in all mammalian species tested to date. The epitope recognized by the 2E3 clone is in the C-terminal non-helical extension of the protein and is unusually resistant to aldehyde fixation, so that this antibody is ideal for studies of paraffin embedded formalin fixed histological sections.Uses Neurofilament α-Internexin/NF66 Monoclonal AntibodyThis antibody is effective in immunoblotting, immunohistochemistry (IHC) immunofluorescence (IF) and can be used on formalin fixed cells. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:10,000*
- IHC: 1:5,000
- IF: 1:500
Notes *Predicted MW = 66kD Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References McGraw TS, et al. Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons. J Neurosci 22:4955-4963, 2002. (IHC)
Evans J, et al. Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol 87:1076-1085, 2002. (WB, IF)
Pachter J, Liem RKH. Alpha-Internexin, a 66-kD intermediate filament-binding protein from mammalian central nervous tissues. J Cell Biol 101:1316-1322, 1985.(GI)Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Neurofilament α-Internexin/NF66 Monoclonal Antibody
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Neurofilament α-Internexin/NF66 Monoclonal Antibody
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