- 询价
- R&D
- ZK-0101167
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Beta Amyloid, 1-16 (6E10) Monoclonal Antibody, F(Ab)2 Fragments (SIGNET)保存于运输说明：
- Store at -20°C or below
- 详细信息：
-
Description Beta Amyloid (Aβ) Monoclonal Antibody, 6E10 F(Ab)2 Fragments
(Formerly Signet Catalog No: 9330-02)
Covance is the Exclusive Provider of this Antibody ProductIntended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone 6E10 Form Purified F(ab’)2 Fragments (in PBS, no preservatives or carrier proteins) Host Beta Amyloid, 1-16 (6E10) Monoclonal Antibody, F(Ab)2 Fragments (SIGNET)Mouse Species Reactivity Human IsoType IgG1 [Ab] 0.5 mg/mL Specificity This antibody is reactive to amino acid residue 1-16 of beta amyloid. The epitope lies within amino acids 3-8 of beta amyloid (EFRHDS). Beta amyloid forms are deposited in the CNS of patients with Alzheimer’s disease and Down’s syndrome. Signet’s beta amyloid antibody 6E10 reacts to the abnormally processed isoforms, as well as precursor forms. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - IHC:
Tissue Sections: Formalin-fixed paraffin-embedded sections
Pretreatment: Formic acid (70%) for 10-30 minutes at room temperature
Storage Store at -20°C or below. Upon initial thawing, apportion into working aliquots and store at -20°C or below. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. Do not store in frost-free freezers. References Thakker DR, et al. Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice. Proc Natl Acad Sci USA Feb 25, 2009.
Beta Amyloid, 1-16 (6E10) Monoclonal Antibody, F(Ab)2 Fragments (SIGNET)Klyubin I, et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat. Med. 11(5):556-61, 2005.
Oddo S, et al. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer’s disease. PNAS 102(8):3046-51, 2005.
Fratta P, et al. Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers. Neurology 63:1114-1117, 2004.
Funamoto S, et al. Truncated carbozkl-terminal fragments of beta- Amyloid precursor protein are processed to Amyloid beta-proteins 40 and 42. Biochemistry 43:13523-13540, 2004.
Herzig M, et al. Abeta is targeted to the vasculature in a mouse model of heredity cerebral hemorrhage with amyloidosis. Nat. Neuro. 7(9):954-959, 2004.
Kim KS, et al. Production and characterization of monoclonal antibodies reactive to synthetic cerebrovascular amyloid peptide. Neurosci. Res. Comm. 2:121-130, 1988.
Kim KS, et al. Neurosci. Res. Comm. 7:113, 1988.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - IHC:
- Beta Amyloid, 1-16 (6E10) Monoclonal Antibody, F(Ab)2 Fragments (SIGNET)
- zk-0296G-zkE-zky3 Goat Anti-Mouse IgG/PE-Cy3PE-Cy3标记的羊抗小鼠IgG
zk-0296G-zky5 Goat Anti-Mouse IgG/Cy5Cy5标记的羊抗小鼠IgG
zk-0296G-zky5.5 Goat Anti-Mouse IgG/Cy5.5Cy5.5标记的羊抗小鼠IgG
zk-0296G-zky7 Goat Anti-Mouse IgG/Cy7Cy7标记的羊抗小鼠IgG
zk-0296G-Azkzk Goat Anti-Mouse IgG/APCAPC标记的羊抗小鼠IgG
zk-0296G-zkE-zky5.5 Goat Anti-Mouse IgG/PE-Cy5.5PE-Cy5.5标记的羊抗小鼠IgG
zk-0368G-Bio Goat Anti-Mouse IgM/Bio生物素标记的羊抗小鼠IgM
zk-0368G-HRzk Goat Anti-Mouse IgM/HRP辣根过氧化物酶标记的羊抗小鼠IgM
zk-0368G-RBITzk Goat Anti-Mouse IgM/RBITC罗丹明标记的羊抗小鼠IgM
zk-0368G-FITzk Goat Anti-Mouse IgM/FITCFITC标记的羊抗小鼠IgM
zk-0368G-AF350 Goat Anti-Mouse IgM/Alexa Fluor 350Alexa Fluor 350标记的羊抗小鼠IgM
zk-0368G-zky3 Goat Anti-Mouse IgM/Cy3Cy3标记的羊抗小鼠IgM
zk-0368G-zky5 Goat Anti-Mouse IgM/Cy5Cy5标记的羊抗小鼠IgM
zk-0368G-zky5.5 Goat Anti-Mouse IgM/Cy5.5Cy5.5标记的羊抗小鼠IgM
zk-0368G-zky7 Goat Anti-Mouse IgM/Cy7Cy7标记的羊抗小鼠IgM
zk-0368G-AF647 Goat Anti-Mouse IgM/Alexa Fluor 647Alexa Fluor 647标记的羊抗小鼠IgM
zk-0368G-Golzk Goat Anti-Mouse IgM/Gold胶体金标记的羊抗小鼠IgM
zk-0293G-Azk Goat Anti-rat IgG/AP碱性磷酸酶（AP）标记的羊抗大鼠IgG
zk-0293G-Golzk Goat Anti-rat IgG/Gold胶体金标记的羊抗大鼠IgG
zk-0293G-FITzk Goat Anti-rat IgG/FITCFITC标记的羊抗大鼠IgG
zk-0293G-HRzk Goat Anti-rat IgG/HRP辣根过氧化物酶标记的羊抗大鼠IgG
zk-0293G-Bio Goat Anti-rat IgG/Bio生物素标记的羊抗大鼠IgG
zk-0293G-zkE-zky3 Goat Anti-rat IgG/PE-Cy3PE-Cy3标记的羊抗大鼠IgG
zk-0293G-zkE-zkY5 Goat Anti-rat IgG/PE-CY5PE-CY5标记的羊抗大鼠IgG
zk-0293G-Azkzk Goat Anti-rat IgG/APCAPC标记的羊抗大鼠IgG
zk-0293G-AF350 Goat Anti-rat IgG/Alexa Fluor 350Alexa Fluor 350标记的羊抗大鼠IgG
zk-0293G-AF488 Goat Anti-rat IgG/Alexa Fluor 488Alexa Fluor 488标记的羊抗大鼠IgG
zk-0293G-zkE-zky5.5 Goat Anti-rat IgG/PE-Cy5.5PE-Cy5.5标记的羊抗大鼠IgG
zk-0293G-zky3 Goat Anti-rat IgG/Cy3Cy3标记的羊抗大鼠IgG
zk-0293G-zky5 Goat Anti-rat IgG/Cy5Cy5标记的羊抗大鼠IgG
zk-0293G-zky5.5 Goat Anti-rat IgG/Cy5.5Cy5.5标记的羊抗大鼠IgG
zk-0293G-zky7 Goat Anti-rat IgG/Cy7Cy7标记的羊抗大鼠IgG
zk-0293G-AF555 Goat Anti-rat IgG/Alexa Fluor 555Alexa Fluor 555标记的羊抗大鼠IgG
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Beta Amyloid, 1-16 (6E10) Monoclonal Antibody, F(Ab)2 Fragments (SIGNET)
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