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- 详细信息
- 技术资料
- 靶点:
来电咨询
- 克隆性:
多克隆
- 标记物:
见 说 明 书
- 宿主:
Goat,Rabbit,Mouse
- 适应物种:
人,大鼠,小鼠,兔
- 形态:
液态/粉状
- 应用范围:
科研使用
- 浓度:
1mg/1ml
- 保存条件:
-20℃保存
- Dopamine Transporter, C-Terminus Polyclonal Antibody保存于运输说明:
- Store at -20°C
- 详细信息:
-
Description Polyclonal Antibody against Dopamine Transporter, C-Terminus Form Affinity Purified Antibody (in10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per mL BSA and 50% glycerol) Host Rabbit Species Reactivity Human, Monkey Specificity Plasmalemmal neurotransmitter transporters sequester synaptic and peri-synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration.
Dopamine Transporter, C-Terminus Polyclonal AntibodyThe antiserum was developed in rabbits against a synthetic peptide from the intracellular C-terminal region of Human Dopamine Transporter (DAT). It was subsequently purified on an affinity column coupled with the immunogen.Uses This antibody is effective in immunoblotting and immunohistochemistry. The antibody recognizes DAT in striatum and formaldehyde-fixed brain sections from human and monkey. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. - Western blot: 1:1,000*
- Dot blot: 1:1,000
- Immunohistochemistry: 1:1,000
Storage Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. For long-term storage, keep antibody at -80°C. References Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J. Neurochem. 87:574-585, 2003.
Dopamine Transporter, C-Terminus Polyclonal AntibodyWilson JM, Kalasinsky KS, Levey AI, Bergeron C, Reiber G, Anthony RM, Schmunk GA, Shannak K, Haycock JW, Kish SJ. Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nature Medicine 2:699-703, 1996.
Erickson JD, Schafer MKH, Bonner TI, Eiden LE, Weihe E. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proc. Natl. Acad. Sci. USA 93:5166-5171, 1996.
Giros B, El Mestikawy S, Godinot N, Zheng K, Han H, Yang-Feng T, Caron MG. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. J. Pharmacol. Exptl. Ther. 56:2139-2142, 1991.
Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Dopamine Transporter, C-Terminus Polyclonal Antibody
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Dopamine Transporter, C-Terminus Polyclonal Antibody
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