IL 17 Human, HEK

IL 17 Human, HEK

• IL 17 Human, HEK
• Interleukin-17 Human Recombinant, HEK
• 2µg ($50)
  10µg ($130)
  1mg ($5200)

   

CATALOGUE NUMBER

CYT-102

SYNONYMS

CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8.

INTRODUCTION

IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cycloozkgenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

DESCRIPTION

IL-17 Human Recombinant produced in HEK cells is a glycosylated homodimer, having a molecular weight range of 30-35kDa due to glycosylation.
The IL-17 is purified by proprietary chromatographic techniques.

SOURCE

HEK.

PHYSICAL APPEARANCE

Sterile Filtered White lyophilized (freeze-dried) powder.

FORMULATION

The IL17 was lyophilized from 1mg/ml in 1xPBS.

SOLUBILITY

It is recommended to reconstitute the lyophilized IL-17 in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

STABILITY

Lyophilized IL-17 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL17 should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

PURITY

Greater than 95% as obsereved by SDS-PAGE.

BIOLOGICAL ACTIVITY

The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts and is typically 5-25ng/ml.

USAGE

ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.