- $1427
- Alomone
- ZK-0039524
- 以色列
- 2025年11月20日
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- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
AK-231
- 克隆性：
多克隆
- 抗原来源：
见 说 明 书
- 保质期：
6个月
- 抗体英文名：
nAChRα Antibody Explorer Kit
- 抗体名：
nAChRα Antibody Explorer Kit
- 标记物：
见官方网站
- 宿主：
见 说 明 书
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
18 Vials
nAChRα Antibody Explorer Kit
A Screening Package of nAChRα Antibodies Economically PricedCat #: AK-231
18 Vials
Alomone Labs is pleased to offer the nAChRα Antibody Explorer Kit (#AK-231). This Explorer Kit includes antibodies targeting nAChRα along with their respective peptide control antigen. An ideal tool for screening purposes.
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-Nicotinic Acetylcholine Receptor α1 (extracellular) |
ANC-001 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α2 (extracellular) |
ANC-002 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α3 (extracellular) |
ANC-003 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α4 (extracellular) |
ANC-004 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α5 (extracellular) |
ANC-005 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α6 (extracellular) |
ANC-006 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α7 (extracellular) |
ANC-007 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α9 |
ANC-019 | 1 x 50 µl |
Anti-Nicotinic Acetylcholine Receptor α10 |
ANC-010 | 1 x 50 µl |
nAChRα Antibody Explorer KitScientific Background
Acetylcholine, released by cholinergic neurons, activates two groups of acetylcholine receptors (AChRs); muscarinic AChRs (mAChRs) which belong to the superfamily of G-protein coupled receptors (GPCRs) and nicotinic AChRs (nAChRs) which belong to the ligand-gated ion channel superfamily. nAChRs also respond to nicotine, hence their name1.
To date, 17 different but related subunits of nAChRs have been identified and cloned. They consist of α subunits (α1-10), which is responsible for the binding of ligands. In fact, this subunit includes a Cys-loop in the first extracellular domain that is required for agonist binding2. The other subunits responsible for making up the active receptor are the β (β1-4), γ, δ and ε subunits3. Structurally, all subunits have the following: a conserved large extracellular N-terminal domain, 3 conserved transmembrane domains, a variable cytoplasmic loop and a fourth transmembrane domain with a short extracellular C-terminal domain. An active nAChR is generally a heteropentamer (homopentamers also exist) of these various subunits organized around a central pore1.
References
- Albuquerque, E.X. et al (2009) Physiol. Rev. 89, 73.
- Karlin, A. et al. (1986) Ann. NY. Acad. Sci. 463, 53.
- Kalamida, D. et al. (2007) FEBS J. 274, 3799.
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