- $37
- Alomone
- ZK-0039520
- 以色列
- 2025年11月20日
- 见官方网站
- Synthetic
- 见官方网站
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- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
H-130
- 克隆性：
多克隆
- 抗原来源：
Synthetic
- 保质期：
6个月
- 抗体英文名：
HMA
- 抗体名：
HMA
- 标记物：
见官方网站
- 宿主：
Synthetic
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
25 mg, 50 mg, 100 mg
HMA
5-(N,N-Hexamethylene) amilorideAn Antagonist of Na+/H+ Exchangers, P2X7 receptors and TRPA1, ASIC3 Channels
Cat #: H-130
Sizes: 25 mg, 50 mg, 100 mg
Source: Synthetic
MW: 311.77 Da.
Target: NHE exchangers, TRPA1, ASIC3 channels, P2X7 receptors
CLICK HERE TO RECEIVE A 25 mg FREE TRIAL SAMPLE!
HMA is a TRPA1 channel blocker with an IC50 value of 35 µM, an inhibitor of the Na+/H+ exchangers (NHE) and a blocker of ASIC3 channel (acid-sensing ion channels)1-3. HMA also antagonizes P2X7 receptors, although it is not potent 4.
HMA as an NHE inhibitor, is considered to be a promising adjuvant drug for overcoming acquired resistance to treatment in various malignant hemopathies1-3.
Alomone Labs is pleased to offer HMA (#H-130).
References
- Banke, T.G. (2011) Brain Res. 1381, 21.
- Masereel, B. et al. (2003) Eur. J. Med. Chem. 38, 547.
- Kuduk, S.D. et al. (2009) Bioorg. Med. Chem. Lett. 19, 2514.
- Chessell, I.P. et al. (1998) Br. J. Pharmacol. 124, 1314.
- Our Bioassay
- Specifications
- Related Products
Alomone Labs HMA inhibits TRPA1 channels activation by AITC in HEK-293 cells.
Dose response curve of HMA (#H-130) inhibition of the TRPA1-mediated, allyl isothiocyanate (AITC)-induced increase in intracellular Ca2+ (IC50 is estimated at 121.9 µM). Cells were loaded with Calcium 5 dye, incubated with HMA, and stimulated with 1 µM allyl isothiocyanate (EC80). Changes in intracellular Ca2+ following stimulation were detected as changes in relative fluorescence (RFU).
Purity>98%.
Effective concentration1-300 µM.
Chemical name3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide.
Molecular formulaC12H18ClN7O.
CAS number1428-95-1.
ActivityHMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal with IC50 of 35 µM1. It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 µM for various NHE isoforms2.HMA also blocks ASIC3 channels by 51% at 20 µM3.
Storage before reconstitutionStore at +4oC.
ReconstitutionUp to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitutionUp to three months at -20°C.
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HMA
$37
