- $98
- Alomone
- ZK-0039458
- 以色列
- 2025年11月20日
- 见官方网站
- Synthetic peptide
- 见官方网站
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- 详细信息
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
STC-750
- 克隆性：
多克隆
- 抗原来源：
Synthetic peptide
- 保质期：
6个月
- 抗体英文名：
ω-Conotoxin CVIA
- 抗体名：
ω-Conotoxin CVIA
- 标记物：
见官方网站
- 宿主：
Synthetic peptide
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
50 µg, 0.1 mg, 0.5 mg, 1 mg
ω-Conotoxin CVIA
A Blocker of N-Type CaV ChannelsCat #: STC-750
Sizes: 50 µg, 0.1 mg, 0.5 mg, 1 mg
Source: Synthetic peptide
MW: 2642 Da.
Net Peptide Content: 100%
Target: CaV2.2 channels
CLICK HERE TO RECEIVE A 50 µg FREE TRIAL SAMPLE!
CaV channels mediate Ca2+ influx through cell membrane as a response to membrane depolarization. N-type channels require strong depolarization for activation and are mostly expressed in neurons where they initiate neurotransmission in fast synapses and mediate Ca2+ entry into cell bodies and dendrites1.
ω-conotoxin CVIA is a 27 amino acid neuropeptide2 belonging to a class of four new ω-conotoxins (CVIA-D) extracted from the venom of the Conus Catus snail. These peptides inhibit neuronal voltage sensitive Ca2+channels in mammals. Interestingly, unlike other ω-conotoxins CVID has a loop 4 sequence and has the highest affinity to N-type channels over other types of Ca2+ channels while CVIA shows a lower affinity to N-type channels.
CVIA is efficient in the management of severe pain, has clinical potential in ischemic brain injury and was also found to inhibit the contraction of electrically stimulated rat vas deferens with an IC50 of 205 nM3.
Alomone labs is pleased to offer ω-Conotoxin CVIA (#STC-750), a highly purified synthetic peptide.
References
- Catterall, W.A. et al. (2005) Pharmacol. Rev. 57, 411.
- Azimi-Zonooz, A. and Litzinger, M.J. (1992) Int. J. Dev. Neurosci. 10, 447.
- Lewis, R.J. et al. (2000) J. Biol. Chem. 275, 35335.
- Our Bioassay
- Specifications
- Related Products
Alomone Labs ω-Conotoxin CVIA inhibits CaV2.2 channels expressed in Xenopus oocytes.
A. Time course of ω-Conotoxin CVIA (#STC-750) action on maximum CaV2.2 channels (α1B + α2δ1 + β1) current elicited in 2 mM Ba2+. Peak current amplitudes were plotted as a function of time. Membrane potential was held at -100 mV and oocytes were stimulated by a 100 ms voltage step to 50 mV. 50 nM ω-Conotoxin CVIA was perfused as indicated by the bar (green) for 5 min. B. Superimposed examples of CaV2.2 channel maximum peak current in the absence (control) and presence (green) of 50 nM ω-Conotoxin CVIA (taken from the experiment in A).
OriginConus catus (cat cone).
Purity>99%.
Effective concentration50-200 nM.
SequenceCKSTGASCRRTSYDCCTGSCRSGRC.
ModificationsDisulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys25. C25 - C-terminal amidation.
Molecular formulaC97H161N39O36S6.
Accession numberP58917
Activityω-Conotoxin CVIA is a N-Type Ca2+ channel blocker1.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionAny aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to two weeks at 4°C or three months at -20°C.
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