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- ZK-0039420
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- 2025年11月20日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海再康生物科技有限公司
- 库存：
大量
- 靶点：
见官方网站
- 级别：
高
- 目录编号：
ESB-002
- 克隆性：
多克隆
- 抗原来源：
见 说 明 书
- 保质期：
6个月
- 抗体英文名：
NaV1.2 Channel Basic Research Pack
- 抗体名：
NaV1.2 Channel Basic Research Pack
- 标记物：
见官方网站
- 宿主：
见 说 明 书
- 适应物种：
见官方网站
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 保存条件：
-20°C
- 规格：
6 Vials
NaV1.2 Channel Basic Research Pack
All You Need for NaV1.2 Channel ResearchCat #: ESB-002
6 Vials
Alomone Labs is pleased to offer the NaV1.2 Channel Basic Research Pack (#ESB-002). The Research Pack contains all you need for NaV1.2 research: An antibody specifically recognizing NaV1.2, classical NaV channel activators and NaV1.2 blockers, all in one economical package!
- Compounds
- Scientific Background
- Related Products
| Product Name | Cat # | Size |
|---|---|---|
Anti-NaV1.2 |
ASC-002 | 1 x 0.2 ml |
ATX-II |
STA-700 | 1 x 0.1 mg |
Lamotrigine |
L-205 | 1 x 250 mg |
α-Pompilidotoxin |
P-170 | 1 x 10 mg |
QX-314•Cl- |
Q-150 | 1 x 100 mg |
Scientific Background
Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.4-5 The Nav channels are classified into two groups according to their sensitivity to Tetrodotoxin (TTX): TTX-sensitive (Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7) and TTX-resistant (Nav1.5, Nav1.8 and Nav1.9).2-3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β subunits. The expression of the α subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain β1 through β4 subunits, whereas sodium channels in adult skeletal muscle have only the β1 subunit.6,7
Nav1.2 is primarily expressed in the central nervous system (CNS) and is localized in unmyelinated or premyelinated axons and dendrites. Mutations in the Nav1.2 channel have been identified in different types of epilepsy.
NaV1.2 Channel Basic Research PackReferences
- Wu, L. et al. (2002) NeuroReport 13, 2547.
- Fang, X. et al. (2002) J. Neurosci. 22, 7425.
- Fjell, J. et al. (2000) NeuroReport 11, 199.
- Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27.
- Lai, J. et al. (2003) Curr. Opin. Neurobiol. 13, 291.
- Isom, L.L. (2001) Neuroscientist 7, 42.
- Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579.
- Catterall, W.A. et al. (2024) J. Neurosci. 28, 11768.
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文献和实验Ion Channels in Analgesia Research
in the management of pain. Using the TRPV1 channel as an example, here we describe some basic biophysical approaches used to study the properties of ion channels involved in pain and in analgesia.
Characterization of Potassium Channel Binding
Library Table of Contents Basic Protocol 1: Measurement of the Binding of [125I]Iberiotoxin to Rat Brain Membranes
Characterization of Calcium Channel Binding
calcium channels are expressed in a variety of tissues including heart, muscles and brain. Saturation binding of a radioligand to the calcium channel is commonly used to characterize the expression level of the channel protein. Compound competition binding
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