T-Type CaV Channel Deluxe Rese

T-Type Ca_V Channel Deluxe Research Pack

All You Need for T-Type Ca_V Channel Research
Cat #: ESD-101
13 Vials

Alomone Labs is pleased to offer the T-Type Ca_V Channel Deluxe Research Pack (#ESD-101). The Research Pack contains all you need for T-Type Ca_V research: Antibodies for each T-type Ca_V channel and specific T-type Ca_V blockers, all in one economical package!

• Compounds
• Scientific Background
• Related Products

Product Name	Cat #	Size
Anti-CaV3.1	ACC-021	1 x 0.2 ml
Anti-CaV3.2	ACC-025	1 x 0.2 ml
Anti-CaV3.3	ACC-009	1 x 0.2 ml
Anti-CaV3.1-ATTO-594	ACC-021-AR	1 x 50 µl
Mibefradil dihydrochloride hydrate	M-150	1 x 10 mg
ML 218 hydrochloride	M-166	1 x 10 mg
NNC 55-0396 dihydrochloride	N-205	1 x 10 mg
SKF 96365 hydrochloride	S-175	1 x 10 mg
TTA-A2	T-140	1 x 10 mg

Scientific Background 

T-type Ca²⁺ channels play an important role in many cellular processes such as hormone secretion, neurotransmitter release and cell differentiation.  

T-type channels are also known to participate in the pacemaker activities of heart and neurons including thalamic neurons.¹ Three genes encoding T-type Ca²⁺ channels have been cloned and designated as Ca_V3.1 (α1G), Ca_V3.2 (α1H) and Ca_V3.3 (α1I).^1-3  

While Ca_V3.1 (α1G) and Ca_V3.2 (α1H) are widely expressed in various tissues, Ca_V3.3 (α1I) is primarily expressed in the central nervous system, where high expression was described in thalamic neurons.  

The Ca²⁺ current generated by the Ca_V3.3 channel displays much slower activation and inactivation compared to the currents produced by Ca_V3.1 and Ca_V3.2, suggesting it might play a different role in neuronal excitability.^1,4

References 

1. Park, J.Y. et al. (2004) J. Biol. Chem. 279, 21707.
2. Chemin, J. et al. (2001) Eur. J. Neurosci. 14, 1678.
3. Monteil, A. et al. (2000) J. Biol. Chem. 275, 16530.
4. Gomora, J.C. et al. (2002) Biophys. J.  83, 229.