- 询价
- R&D
- ZK-0002904
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- ProBACE1 B693 Polyclonal Antibody保存于运输说明：
- Store at -20°C. Upon initial thawing
- 详细信息：
-
Description Polyclonal Antibody against ProBACE1 (B693) Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Form Antiserum Host ProBACE1 B693 Polyclonal AntibodyRabbit Species Reactivity Human, Mouse, Rat Specificity Processing of the β-amyloid precursor protein (βAPP) by two endopeptidases, β and γ secretases generates the amyloidogenic peptide Aβ, a major factor in the etiology of Alzheimers disease. The beta secretase is a novel membrane bound aspartyl protease which cleaves the β-APP to generate the N-terminus of the Aβ domain. The membrane bound C-terminal fragment generated by the beta secretase cut is subsequently cleaved by the gamma secretase, resulting in the generation and secretion of Aβ.
B693 was raised against a peptide sequence CGIRLPLRSGLGGAPLGLRLPR; 22 amino acids of the human proBACE1.Uses This antibody is effective in immunoblotting, immunoprecipitation (IP) and immunostaining. Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:1,000
- IP: 1:200
- Immunostaining: 1:300
Storage ProBACE1 B693 Polyclonal AntibodyStore at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Yan R, Han P, Miao H, Greengard P, Xu H. The transmembrane domain of the Alzheimers beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate. J Biol Chem 276(39):36788-36796, 2001. Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - ProBACE1 B693 Polyclonal Antibody
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ProBACE1 B693 Polyclonal Antibody
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