- 询价
- R&D
- ZK-0002243
- 美国/中国
- 2025年11月20日
- 科研使用
- Goat，Rabbit，Mouse
- 人，大鼠，小鼠，兔
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- 详细信息
- 技术资料
- 靶点：
来电咨询
- 克隆性：
多克隆
- 标记物：
见 说 明 书
- 宿主：
Goat，Rabbit，Mouse
- 适应物种：
人，大鼠，小鼠，兔
- 形态：
液态/粉状
- 应用范围：
科研使用
- 浓度：
1mg/1ml
- 保存条件：
-20℃保存
- Detyrosinated α-Tubulin Monoclonal Antibody, Purified保存于运输说明：
- Store at -20°C
- 详细信息：
-
Description Purified Monoclonal Antibody against Detyrosinated α-Tubulin Intended Use **Research Use Only (RUO)**
This product is sold for laboratory research use only, not for human or in-vivo use.Clone AA12 Form Purified Antibody (in PBS + 0.03% thimerosal) Host Mouse Species Reactivity Detyrosinated α-Tubulin Monoclonal Antibody, Purified Mammalian IsoType IgG2a Specificity Microtubules are required for many well characterized functions in eukaryotic cells, including the movement of chromosomes in mitosis and meiosis, intracellular transport, establishment and maintenance of cellular morphology, cell growth, cell migration and morphogenesis in multicellular organisms. The building block of a microtubule is the tubulin subunit, a heterodimer of α- and β-tubulin. Both of these monomers are found in all eukaryotes, and their sequences are highly conserved. The tubulin protein is a major target of drug molecules, and consequently, tubulin inhibitors have attracted great attention as antimitotic antitumor agents for chemotherapeutic use. This antibody recognizes detyrosinated α-tubulin, a post translational modification of α-tubulin. This antibody was raised against the peptide sequence CGEEEGE and purified on a protein G column. Uses This antibody is effective in immunoblotting and immunofluorescence (IF). Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. - Western blot: 1:1,000*
- IF: 1:1,000
Notes *Predicted MW = 55 kDa Storage Detyrosinated α-Tubulin Monoclonal Antibody, Purified Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C. References Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM. Reduction of Detyrosinated Microtubules and Golgi Fragmentation Are Linked to Tau-Induced Degeneration in Astrocytes. J Neurosci 23:10662 - 10671, 2003.
Mialhe A, Lafanechere L, Treilleux I, Peloux N, Dumontet C, Bremond A, Panh MH, Payan R, Wehland J, Margolis RL, Job D. Tubulin Detyrosination Is a Frequent Occurrence in Breast Cancers of Poor Prognosis. Cancer Res 61:5024 - 5027, 2001.
Idriss HT. Man to trypanosome: the tubulin tyrosination/detyrosination cycle revisited. Cell Motil Cytoskeleton 45(3):173-84, 2000.Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval. - Detyrosinated α-Tubulin Monoclonal Antibody, Purified
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Detyrosinated α-Tubulin Monoclonal Antibody, Purified
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