多配体蛋白聚糖2/硫酸肝素糖蛋白1抗体

多配体蛋白聚糖2/硫酸肝素糖蛋白1抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

多配体蛋白聚糖2/硫酸肝素糖蛋白1抗体产品说明

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.
Heparan Sulfate Proteoglycan is found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, HSPG2 has been strongly implicated in the control of tumour cell growth and metastatic behavior. HSPG2 possesses angiogenic and growth promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF2).
Proteoglycans are macromolecules consisting of a variety of core proteins with covalently attached one or several polysaccharide chains of the glycosaminoglycan type (heparan sulphate, heparin, chondroitin sulphate, dermatan sulphate or keratan sulphate). At least two forms of basement membrane heparan sulphate proteoglycan (HSPG) have been identified. One with a large core protein (> 400 kD) and one with a small core protein (30 kD). The large HSPG is probably the most abundant basement membrane proteoglycan. It is located predominantly in the lamina lucida, where it forms clustered aggregates and interacts with other basement membrane components to form the matrix. In addition, it also plays a critical role in attachment of cells to the basal membrane via integrin receptors.
mol wt:20kDa
Other Aliases:
heparin sulphate protoglycans 1; Sdc2; 4833414L08Rik; AA960457; Hspg1; Synd2; syndecan-2

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