卵磷胆固醇酰基转移酶抗体

卵磷胆固醇酰基转移酶抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

卵磷胆固醇酰基转移酶抗体产品介绍

LCAT是参与体内脂质代谢的主要成份之一，是一种在高密度脂蛋白(HDL)代谢和动脉粥样硬化(AS)发展中的关键酶。LCAT需要经载脂蛋白ApoAI、载脂蛋白D(ApoD)作为辅助因子并经ApoE活化来发挥作用。
This gene encodes the extracellular cholesterol esterifying enzyme, lecithin cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish eye disease as well as LCAT deficiency.
LCAT is the plasma enzyme responsible for most HDL cholesteryl esters in human plasma. In species with cholesteryl ester transfer protein (CETP) it is also responsible for a significant proportion of VLDL and LDL cholesteryl esters. LCAT, through the esterification of cholesterol, plays a role in the reverse cholesterol transport pathway by facilitating the net movement of cholesterol from peripheral tissues back to the liver for excretion. LCAT deficiency results in low levels of plasma HDL, whereas a transgenic overexpression of LCAT results in increased plasma HDL concentrations.
mol wt:48kDa
Other Aliases:
Lecithin cholesterol acyltransferase; Phosphatidylcholine sterol acyltransferase; Phospholipid cholesterol acyltransferase; MGC108718

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卵磷胆固醇酰基转移酶抗体