BioSIM 抗人 PCSK9 抗体 (洛迪赛珠单抗)，生物

BioSIM 抗人 PCSK9 抗体 (洛迪赛珠单抗)

英文名称：BioSIM anti-Human PCSK9 Antibody (Lodelcizumab Biosimilar), Research Grade
CAS号：1355338-54-3
产品类型：二抗
供应商：InvivoCrown
产品货号：SIM0537-5mg
产品规格：5mg

产品概述

BioSIM 抗人 PCSK9 抗体是一种高特异性的生物类似药，专为科研用途设计。该抗体针对人源PCSK9(前蛋白转换酶枯草溶菌素/kexin类型9)蛋白，广泛应用于高胆固醇血症相关研究领域。作为洛迪赛珠单抗的生物类似药，该抗体在结构和功能上模拟原研药物，为研究者提供经济高效的实验选择。

生产与纯化特点

该重组生物类似抗体采用先进的无动物成分生产工艺，在无动物成分的设施中生产，仅使用体外的无蛋白细胞培养技术，确保了产品的纯净度和安全性。生产过程中经过多步骤的纯化，其中包括采用Protein A或G的色谱工艺，保证了抗体的高纯度和低内毒素含量，适用于多种敏感的实验应用。

研究领域与应用

研究领域：原发性高胆固醇血症
应用类型：ELISA, FACS, Functional assay, Research in vivo

该抗体适用于多种实验平台，可用于：

• ELISA实验中对PCSK9蛋白的定量检测
• 流式细胞术(FACS)中对表达PCSK9的细胞进行检测和分选
• 功能测定评估抗体与PCSK9的相互作用及其对胆固醇代谢的影响
• 体内动物模型研究，探索PCSK9在胆固醇调节中的作用机制

抗体特性

来源宿主：Humanized
反应性：Human

该抗体为人源化设计，降低了在实验中的非特异性结合风险，提高了与人类靶点的亲和力和特异性，特别适合人类相关疾病机制的研究。

保存建议

为确保抗体活性和稳定性，请遵循以下保存条件：

• 避免反复冻融，以防止抗体活性下降
• 短期需求（1-2周）请在4°C下保存
• 最长12个月的储存请在-20°C下保存
• 长期储存请在-80°C下保存

建议分装保存，以减少反复冻融对抗体活性的影响。

免疫原信息

BioSIM 抗人 PCSK9 抗体的免疫原性详情请参考该产品的说明书，其中包含关于抗体免疫反应的全面信息，有助于实验设计中的风险评估。

订购信息

产品货号：SIM0537-5mg
规格：5mg
供应商：InvivoCrown

该抗体专为B2B科研市场设计，适用于制药公司、生物技术企业和研究机构的研发项目。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human PCSK9 Antibody (Lodelcizumab Biosimilar)

English Name:BioSIM anti-Human PCSK9 Antibody (Lodelcizumab Biosimilar), Research Grade
CAS Number:1355338-54-3
Product Type:Secondary Antibody
Supplier:InvivoCrown
Catalog Number:SIM0537-5mg
Product Specification:5mg

Product Overview

BioSIM Anti-Human PCSK9 Antibody is a highly specific biosimilar designed for research purposes. This antibody targets human PCSK9 (proprotein convertase subtilisin/kexin type 9) protein and is widely used in research related to hypercholesterolemia. As a biosimilar of Lodelcizumab, this antibody mimics the original drug in structure and function, providing researchers with a cost-effective experimental option.

Production and Purification Features

This recombinant biosimilar antibody is produced using advanced animal-free production processes in animal-free facilities, utilizing only in vitro protein-free cell culture technology to ensure product purity and safety. The production process involves multi-step purification, including chromatography with Protein A or G, ensuring high purity and low endotoxin content of the antibody, suitable for various sensitive experimental applications.

Research Areas and Applications

Research Areas:Primary Hypercholesterolemia
Application Types:ELISA, FACS, Functional assay, Research in vivo

This antibody is suitable for multiple experimental platforms and can be used for:

• Quantitative detection of PCSK9 protein in ELISA experiments
• Detection and sorting of PCSK9-expressing cells by flow cytometry (FACS)
• Functional assays to evaluate antibody interaction with PCSK9 and its effects on cholesterol metabolism
• In vivo animal model studies to explore the mechanism of PCSK9 in cholesterol regulation

Antibody Characteristics

Source Host:Humanized
Reactivity:Human

This antibody is designed as humanized, reducing the risk of non-specific binding in experiments and improving affinity and specificity for human targets, making it particularly suitable for studying human disease mechanisms.

Storage Recommendations

To ensure antibody activity and stability, please follow the following storage conditions:

• Avoid repeated freeze-thaw cycles to prevent loss of antibody activity
• For short-term needs (1-2 weeks), store at 4°C
• For storage up to 12 months, store at -20°C
• For long-term storage, store at -80°C

It is recommended to store in aliquots to reduce the effects of repeated freeze-thaw cycles on antibody activity.

Immunogenicity Information

For detailed information on the immunogenicity of BioSIM Anti-Human PCSK9 Antibody, please refer to the product manual, which contains comprehensive information about antibody immune responses, helping with risk assessment in experimental design.

Ordering Information

Catalog Number: SIM0537-5mg
Specification: 5mg
Supplier: InvivoCrown

This antibody is designed for the B2B research market and is suitable for R&D projects in pharmaceutical companies, biotechnology enterprises, and research institutions.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yaokeen Company.