BioSIM 抗人 TIGIT 抗体 (艾替利单抗)，生物类

BioSIM 抗人 TIGIT 抗体 (艾替利单抗)，生物类似药，科研用途

产品概述

BioSIM anti-Human TIGIT Antibody (Etigilimab Biosimilar) 是一款专为免疫肿瘤学研究设计的高质量科研级生物类似抗体。TIGIT（T细胞免疫球蛋白和ITIM结构域）作为新兴的免疫检查点分子，在调节T细胞功能、维持免疫稳态以及肿瘤免疫逃逸中扮演关键角色。作为艾替利单抗的生物类似药，该产品采用先进的体外无蛋白细胞培养技术生产，确保了高纯度和批次一致性，为研究人员提供可靠的TIGIT靶向研究工具。

产品特性

• 高特异性与亲和力：针对人源TIGIT蛋白，具有优异的靶点结合能力和选择性
• 无动物成分生产：在无动物成分的设施中生产，彻底消除动物源病原体和异源蛋白污染风险，提高实验结果的可重复性
• 多步纯化工艺：经过包括Protein A/G色谱在内的多步纯化过程，确保产品达到科研级纯度标准
• 人源化设计：Humanized来源宿主，提高与人体生物系统的相容性，减少非特异性结合
• 广泛适用性：兼容多种实验平台，从体外分子检测到体内动物模型研究，满足不同研究需求

技术参数

研究领域与应用

该抗体专注于以下癌症研究领域，助力科学家深入探索TIGIT在肿瘤免疫微环境中的作用机制：

• 腹膜癌：研究TIGIT在腹膜转移微环境中的免疫调节作用，探索联合免疫治疗的潜在策略
• 卵巢癌：分析TIGIT在卵巢癌免疫逃逸机制中的功能，评估其作为治疗靶点的可行性
• 输卵管癌：研究TIGIT信号通路在输卵管癌发展中的影响，为精准治疗提供理论基础

应用类型：

• ELISA：适用于TIGIT蛋白的定量检测和表达分析，支持高通量筛选实验
• FACS：可用于表达TIGIT的细胞亚群分选与鉴定，分析肿瘤浸润免疫细胞表型
• Functional assay：评估TIGIT信号通路的生物学功能，研究其对T细胞增殖、活化和细胞因子分泌的影响
• Research in vivo：支持构建动物模型，研究TIGIT靶向治疗的体内效果和机制

储存与稳定性

为确保产品质量和稳定性，请遵循以下储存条件：

• 避免反复冻融：防止蛋白降解和活性损失，建议分装保存
• 短期储存（1-2周）：4°C保存，适合频繁使用的实验室
• 中期储存（最长12个月）：-20°C保存，推荐使用防冻管分装
• 长期储存：-80°C保存，确保产品长期稳定性

使用建议

为确保最佳实验结果，建议在使用前：

• 仔细阅读产品说明书，了解详细的免疫原信息和潜在交叉反应性
• 根据具体应用需求优化抗体浓度和实验条件，可通过预实验确定最佳工作浓度
• 使用适当的对照实验，包括同型对照和阴性对照，确保结果的特异性
• 注意无菌操作，防止样品污染，特别是在进行细胞培养相关实验时
• 对于体内研究，请遵循动物伦理规范和相关实验操作指南

包装信息

产品以5mg规格包装，采用高质量冻干粉形式提供，确保运输过程中的稳定性。每瓶产品均配有详细的产品信息和使用说明。收到产品后，请按照储存条件妥善保管，并在有效期内使用。如需更大或更小规格，请联系供应商获取定制化解决方案。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Anti-Human TIGIT Antibody (Etigilimab Biosimilar), for Research Use

Product Overview

BioSIM anti-Human TIGIT Antibody (Etigilimab Biosimilar) is a high-quality research-grade biosimilar antibody specifically designed for immuno-oncology research. TIGIT (T cell immunoglobulin and ITIM domain), as an emerging immune checkpoint molecule, plays a crucial role in regulating T cell function, maintaining immune homeostasis, and tumor immune escape. As a biosimilar of Etigilimab, this product is produced using advanced animal-free cell culture technology, ensuring high purity and batch consistency, providing researchers with a reliable TIGIT-targeted research tool.

Product Features

• High Specificity and Affinity: Targets human TIGIT protein with excellent target binding capability and selectivity
• Animal-Free Production: Produced in animal-free facilities, completely eliminating the risk of animal-derived pathogens and heterologous protein contamination, improving experimental result reproducibility
• Multi-step Purification Process: Undergoes multi-step purification including Protein A/G chromatography to ensure the product meets research-grade purity standards
• Humanized Design: Humanized source host, enhancing compatibility with human biological systems and reducing non-specific binding
• Broad Applicability: Compatible with various experimental platforms, from in vitro molecular detection to in vivo animal model studies, meeting diverse research needs

Technical Parameters

Research Areas and Applications

This antibody focuses on the following cancer research areas, helping scientists to explore in depth the mechanism of TIGIT in the tumor immune microenvironment:

• Peritoneal Cancer: Research on the immunomodulatory effects of TIGIT in the peritoneal metastasis microenvironment, exploring potential strategies for combination immunotherapy
• Ovarian Cancer: Analysis of TIGIT's function in ovarian cancer immune escape mechanisms, evaluating its feasibility as a therapeutic target
• Fallopian Tube Cancer: Research on the impact of TIGIT signaling pathways in fallopian tube cancer development, providing a theoretical basis for precision therapy

Application Types:

• ELISA: Suitable for quantitative detection and expression analysis of TIGIT protein, supporting high-throughput screening experiments
• FACS: Can be used for sorting and identification of TIGIT-expressing cell subsets, analyzing phenotypes of tumor-infiltrating immune cells
• Functional assay: Evaluate the biological functions of TIGIT signaling pathways, studying its effects on T cell proliferation, activation, and cytokine secretion
• Research in vivo: Supports the construction of animal models to study the in vivo effects and mechanisms of TIGIT-targeted therapy

Storage and Stability

To ensure product quality and stability, please follow the following storage conditions:

• Avoid repeated freeze-thaw cycles: Prevent protein degradation and activity loss, aliquot storage is recommended
• Short-term storage (1-2 weeks): Store at 4°C, suitable for laboratories with frequent use
• Medium-term storage (up to 12 months): Store at -20°C, aliquoting in cryovials is recommended
• Long-term storage: Store at -80°C to ensure long-term product stability

Usage Recommendations

To ensure optimal experimental results, it is recommended to:

• Read the product manual carefully to understand detailed immunogenicity information and potential cross-reactivity
• Optimize antibody concentration and experimental conditions based on specific application requirements, determine optimal working concentration through preliminary experiments
• Use appropriate control experiments, including isotype controls and negative controls, to ensure result specificity
• Maintain aseptic techniques to prevent sample contamination, especially when conducting cell culture-related experiments
• For in vivo research, follow animal ethics guidelines and relevant experimental protocols

Packaging Information

The product is packaged in 5mg specifications, provided in high-quality lyophilized powder form to ensure stability during transportation. Each product bottle comes with detailed product information and usage instructions. Upon receipt, please store the product properly according to storage conditions and use within the expiration date. For larger or smaller specifications, please contact the supplier for customized solutions.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yacoin Biotechnology.