BioSIM 抗人 CD14 抗体 (阿替布利单抗)，生物类

产品基本信息

• 英文名称：BioSIM anti-Human CD14 Antibody (Atibuclimab Biosimilar), Research Grade
• 中文名称：BioSIM 抗人 CD14 抗体 (阿替布利单抗)，生物类似药，科研用途
• CAS号：2417175-94-9
• 产品类型：二抗
• 供应商：InvivoCrown
• 产品货号：SIM0062-5mg
• 产品规格：5mg

产品核心特性

• 来源宿主：Chimeric（嵌合抗体，含鼠源可变区与人源IgG4 Fc片段）
• 反应性：Human（特异性识别人源CD14抗原）
• 免疫原信息：具体细节请参考产品说明书

产品背景与作用机制

本品为阿替布利单抗的非治疗性生物类似药，与原研抗体具有相同的可变区序列，适用于科研领域的机制探索。

靶向抗原CD14是先天免疫的关键模式识别受体（PAMP受体），同时作为LPS（脂多糖）的辅助受体，主要表达于单核细胞、巨噬细胞表面。

作用机制：通过阻断CD14与LPS的相互作用，可降低下游TLR4（Toll样受体4）的活化水平，进而调控炎症反应相关信号通路。

适用研究领域与应用场景

研究方向

• 成人呼吸窘迫综合征（ARDS）
• 急性肺损伤（ALI）
• CD14信号传导机制研究
• 先天免疫应答调控研究

应用类型

• ELISA（酶联免疫吸附实验）
• FACS（荧光激活细胞分选）
• Functional assay（功能实验）
• In vivo研究（体内实验）

储存与稳定性建议

• 短期使用（1-2周内）：4℃避光保存（避免反复冻融）
• 中期储存（最长12个月）：-20℃避光保存（建议分装为单次使用量）
• 长期储存（超12个月）：-80℃避光保存（分装后可维持稳定活性）
• 关键注意：反复冻融会导致抗体活性下降，需严格避免

重要提示

本品为科研用途生物类似药，仅用于实验室研究，不得用于人体诊断、治疗或临床用途；非药物产品，不具备临床治疗功效。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Basic Product Information

• English Name: BioSIM anti-Human CD14 Antibody (Atibuclimab Biosimilar), Research Grade
• Chinese Name: BioSIM anti-Human CD14 Antibody (Atibuclimab), Biosimilar, Research Use
• CAS Number: 2417175-94-9
• Product Type: Secondary Antibody
• Supplier: InvivoCrown
• Catalog Number: SIM0062-5mg
• Specification: 5mg

Core Product Characteristics

• Host Source: Chimeric (Chimeric antibody containing murine variable regions and human IgG4 Fc fragment)
• Reactivity: Human (Specifically recognizes human CD14 antigen)
• Immunogen Information: For specific details, please refer to the product manual

Product Background and Mechanism of Action

This product is a non-therapeutic biosimilar of Atibuclimab, possessing identical variable region sequences to the original antibody, suitable for mechanism exploration in research fields.

The target antigen CD14 is a key pattern recognition receptor (PAMP receptor) in innate immunity, while also serving as a co-receptor for LPS (lipopolysaccharide), primarily expressed on the surface of monocytes and macrophages.

Mechanism of Action: By blocking the interaction between CD14 and LPS, it reduces the activation level of downstream TLR4 (Toll-like receptor 4), thereby regulating inflammatory response-related signaling pathways.

Applicable Research Fields and Application Scenarios

Research Directions

• Adult Respiratory Distress Syndrome (ARDS)
• Acute Lung Injury (ALI)
• CD14 signaling mechanism research
• Innate immune response regulation research

Application Types

• ELISA (Enzyme-Linked Immunosorbent Assay)
• FACS (Fluorescence-Activated Cell Sorting)
• Functional assay
• In vivo studies

Storage and Stability Recommendations

• Short-term use (within 1-2 weeks): Store at 4°C protected from light (avoid repeated freeze-thaw cycles)
• Medium-term storage (up to 12 months): Store at -20°C protected from light (aliquoting into single-use portions is recommended)
• Long-term storage (over 12 months): Store at -80°C protected from light (stable activity can be maintained after aliquoting)
• Key Note: Repeated freeze-thaw cycles will lead to decreased antibody activity and must be strictly avoided

Important Notice

This product is a research-use biosimilar intended only for laboratory research and not for human diagnosis, treatment, or clinical use; it is not a drug product and does not possess therapeutic effects.

Note: The above information may be subject to change due to product optimization and upgrades. For specific information, please contact InvivoCrown.