BioSIM 抗人 FcRn 抗体 (尼卡利单抗 / 尼泊卡

产品核心信息

英文名称：BioSIM anti-Human FcRn Antibody (Nipocalimab Biosimilar), Research Grade

中文名称：BioSIM 抗人 FcRn 抗体（尼卡利单抗/尼泊卡利单抗），生物类似药，科研用途

CAS号：2211985-36-1

供应商与规格

供应商：InvivoCrown

产品货号：SIM0056-5mg

产品规格：5mg

产品类型与背景

产品类型

二抗（人源FcRn靶向生物类似药抗体，科研级）

背景资料

本产品为非治疗性尼卡利单抗（Nipocalimab）生物仿制药，保留与原研药一致的可变区结构，仅用于科研场景。

靶向靶点FcRn（新生儿Fc受体）是调控IgG稳态的核心分子，广泛表达于内皮细胞、上皮细胞、单核细胞等细胞类型中。

抗体作用机制：通过阻断内源性IgG与FcRn的结合，加速IgG分解代谢，降低循环IgG水平（该过程与IgG介导的自身免疫病病理相关）。

适用研究方向：

• FcRn的生物学功能解析
• IgG清除的分子机制研究
• FcRn靶向干预的治疗潜力探索

重点研究领域：全身型重症肌无力（gMG）

应用与反应性

应用类型

支持以下科研实验：

• ELISA（酶联免疫吸附实验）
• FACS（荧光激活细胞分选）
• Functional assay（功能实验）
• Research in vivo（体内研究）

反应性

目标物种：Human（人源）

来源宿主

宿主：Human（人源抗体）

保存建议

储存规范

为维持抗体活性，需遵循以下条件：

• 短期使用（1-2周）：4°C避光保存
• 中期储存（最长12个月）：-20°C避光保存
• 长期储存（＞12个月）：-80°C避光保存
• 注意：避免反复冻融，以免影响抗体活性

免疫原说明

本产品免疫原信息请参考随附说明书，或联系供应商获取详细资料。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

Product Core Information

English Name:BioSIM anti-Human FcRn Antibody (Nipocalimab Biosimilar), Research Grade

Chinese Name:BioSIM anti-Human FcRn Antibody (Nipocalimab), Biosimilar, Research Use

CAS Number:2211985-36-1

Supplier and Specifications

Supplier:InvivoCrown

Product Catalog Number:SIM0056-5mg

Product Size:5mg

Product Type and Background

Product Type

Secondary Antibody (Human FcRn-targeting Biosimilar Antibody, Research Grade)

Background Information

This product is a non-therapeutic Nipocalimab biosimilar that retains the variable region structure consistent with the original drug and is intended for research purposes only.

The target FcRn (Neonatal Fc Receptor) is a core molecule that regulates IgG homeostasis and is widely expressed in endothelial cells, epithelial cells, monocytes, and other cell types.

Antibody Mechanism of Action: By blocking the binding of endogenous IgG to FcRn, it accelerates IgG catabolism and reduces circulating IgG levels (a process related to the pathology of IgG-mediated autoimmune diseases).

Applicable Research Directions:

• Analysis of FcRn biological functions
• Study of molecular mechanisms of IgG clearance
• Exploration of therapeutic potential of FcRn-targeted interventions

Key Research Areas: Generalized Myasthenia Gravis (gMG)

Application and Reactivity

Application Types

Supports the following research applications:

• ELISA (Enzyme-Linked Immunosorbent Assay)
• FACS (Fluorescence-Activated Cell Sorting)
• Functional assay
• Research in vivo

Reactivity

Target Species:Human

Host Species

Host:Human (Human Antibody)

Storage Recommendations

Storage Guidelines

To maintain antibody activity, the following conditions should be followed:

• Short-term use (1-2 weeks): Store at 4°C protected from light
• Medium-term storage (up to 12 months): Store at -20°C protected from light
• Long-term storage (>12 months): Store at -80°C protected from light
• Note: Avoid repeated freeze-thaw cycles to maintain antibody activity

Immunogen Information

For immunogen information of this product, please refer to the accompanying instructions or contact the supplier for detailed information.

Note: The above information may change due to product optimization and upgrades. Please consult InvivoCrown for specific information.