BioSIM 抗狗 NGF 抗体 (雷奈韦单抗)，生物类似药

产品核心信息

基本标识

英文名称：BioSIM anti-Dog NGF Antibody (Ranevetmab Biosimilar), Research Grade

中文名称：BioSIM 抗狗 NGF 抗体 (雷奈韦单抗)，生物类似药，科研用途

CAS号：1632282-27-9

产品类型：二抗（犬NGF特异性结合抗体）

供应商：InvivoCrown

货号：SIM0080-1mg

规格：1mg/支

生产背景与工艺

产品定位

本产品为雷奈韦单抗（Ranevetmab）的生物类似药，针对犬神经生长因子（NGF）设计，仅用于科研用途，不涉及临床应用。

生产工艺特点

• 生产设施：无动物成分（Animal-Free）的洁净生产环境，降低外源性污染物引入风险；
• 细胞培养：采用体外无蛋白细胞培养技术，避免血清等动物源成分对产品纯度的干扰；
• 纯化工艺：多步骤纯化流程，包含Protein A/G亲和色谱工艺，有助于提升抗体纯度与批间一致性。

研究领域与应用

核心研究方向

犬退行性关节病（Canine Degenerative Joint Disease, DJD）——NGF在犬DJD的疼痛信号传导、软骨损伤进展中起关键调控作用，本产品为该领域的机制研究、靶点验证提供工具支持。

适用实验类型

• ELISA：用于犬类生物样本（血清、关节液等）中NGF蛋白的定性/定量检测；
• FACS：适用于细胞水平（如关节软骨细胞、神经细胞）的NGF表达分析（表面/胞内染色）；
• Functional Assay：可用于NGF生物活性的中和实验、信号通路激活/抑制验证；
• In Vivo Research：支持犬类模型中NGF相关病理机制的体内干预研究（需遵循动物实验伦理规范）。

关键特性

抗体来源与特异性

来源宿主：Caninized（犬源化）——经工程化改造的犬源化单克隆抗体，降低异源免疫反应风险，更适配犬类研究体系；

反应性：仅特异性结合犬（Dog）NGF蛋白，无交叉反应性（需结合实验验证）；

免疫原信息：请查阅随附产品说明书，获取详细免疫原设计与制备背景。

保存与稳定性建议

储存条件（避免反复冻融）

• 短期需求（1-2周）：4°C避光保存；
• 中期储存（≤12个月）：-20°C避光保存（建议分装为小体积，避免多次冻融）；
• 长期储存（＞12个月）：-80°C避光保存，可进一步延长有效使用周期。

注意：每次取用后请立即恢复至对应储存温度，避免产品暴露于室温过久。

供应商说明

InvivoCrown 专注于科研级生物类似药、重组蛋白与抗体工具的研发与生产，依托严格的质量控制体系，为生命科学领域（尤其是兽医研究、模式动物研究）提供可靠的生物试剂支持。

Product Core Information

Basic Identification

English Name: BioSIM anti-Dog NGF Antibody (Ranevetmab Biosimilar), Research Grade

Chinese Name: BioSIM Anti-Dog NGF Antibody (Ranevetmab), Biosimilar, Research Use

CAS Number: 1632282-27-9

Product Type: Secondary Antibody (Canine NGF-specific Binding Antibody)

Supplier: InvivoCrown

Catalog Number: SIM0080-1mg

Specification: 1mg/vial

Production Background and Process

Product Positioning

This product is a biosimilar of Ranevetmab, designed specifically against canine Nerve Growth Factor (NGF), intended for research use only and not for clinical applications.

Manufacturing Process Characteristics

• Production Facility: Animal-Free clean manufacturing environment, reducing the risk of introducing exogenous contaminants;
• Cell Culture: Utilizes in vitro protein-free cell culture technology, avoiding interference from animal-derived components such as serum on product purity;
• Purification Process: Multi-step purification process, including Protein A/G affinity chromatography, helping to improve antibody purity and batch-to-batch consistency.

Research Fields and Applications

Core Research Areas

Canine Degenerative Joint Disease (DJD) - NGF plays a key regulatory role in pain signal transduction and cartilage damage progression in canine DJD. This product provides tool support for mechanistic studies and target validation in this field.

Suitable Experimental Types

• ELISA: For qualitative/quantitative detection of NGF protein in canine biological samples (serum, synovial fluid, etc.);
• FACS: Suitable for NGF expression analysis at the cellular level (e.g., articular chondrocytes, nerve cells) (surface/intracellular staining);
• Functional Assay: Can be used for neutralization experiments of NGF biological activity, verification of signaling pathway activation/inhibition;
• In Vivo Research: Supports in vivo intervention studies of NGF-related pathological mechanisms in canine models (must follow animal experimental ethics guidelines).

Key Characteristics

Antibody Source and Specificity

Source Host: Caninized - Engineered caninized monoclonal antibody, reducing the risk of heterologous immune reactions, more suitable for canine research systems;

Reactivity: Specifically binds to Canine (Dog) NGF protein only, with no cross-reactivity (requires experimental verification);

Immunogen Information: Please refer to the accompanying product manual for detailed immunogen design and preparation background.

Storage and Stability Recommendations

Storage Conditions (Avoid Repeated Freeze-Thaw Cycles)

• Short-term (1-2 weeks): Store at 4°C protected from light;
• Medium-term storage (≤12 months): Store at -20°C protected from light (recommend aliquoting into small volumes to avoid multiple freeze-thaw cycles);
• Long-term storage (>12 months): Store at -80°C protected from light, which can further extend the effective usage period.

Note: Please immediately return to the corresponding storage temperature after each use, avoiding prolonged exposure of the product to room temperature.

Supplier Description

InvivoCrown specializes in the research, development, and production of research-grade biosimilars, recombinant proteins, and antibody tools. Relying on a strict quality control system, we provide reliable biological reagent support for the life sciences field (especially veterinary research and model animal research).