BioSIM 人 Bispecific gp100 pept

BioSIM 人双特异性gp100肽&HLA-A*02:01（特本塔夫斯普/替本福司）生物类似药 科研级

一、核心产品信息

• 英文全称：BioSIM Human Bispecific gp100 peptide & HLA-A*02:01 (Tebentafusp Biosimilar), Research Grade
• 中文全称：BioSIM 人双特异性gp100肽&HLA-A*02:01（特本塔夫斯普/替本福司）生物类似药 科研用途
• CAS编号：1874157-95-5
• 产品货号：SIM0736-5mg
• 产品类型：重组蛋白
• 规格：5mg/支
• 供应商：InvivoCrown

二、生产背景与工艺特性

本产品为特本塔夫斯普（Tebentafusp）的重组生物类似药，生产过程严格遵循科研级产品标准：

• 生产环境：无动物设施，规避动物源污染物对实验结果的潜在干扰；
• 表达系统：哺乳动物细胞表达，保障蛋白天然折叠与活性；
• 培养工艺：体外无蛋白细胞培养技术，减少杂蛋白对纯化及后续实验的影响；
• 纯化流程：多步色谱纯化（含蛋白A/G亲和色谱），提升产品纯度与均一性。

三、科研应用方向

本产品仅用于科学研究，主要适配以下领域：

• 黑色素瘤发病机制研究；
• 葡萄膜黑色素瘤（眼癌）靶向治疗机制研究；
• 免疫检查点相关的肿瘤免疫研究。

四、缓冲液体系详情

产品溶解于以下稳定缓冲液中：

• 9 mM 一水柠檬酸（Citric acid monohydrate）；
• 41 mM 磷酸氢二钠（Na₂HPO₄）；
• 1% 甘露醇（Mannitol）；
• 5% 海藻糖（Trehalose）；
• 0.02% 吐温20（Tween 20）；
• 2 mM 二硫苏糖醇（DTT）；
• pH值：6.5（25℃条件下）。

五、储存与稳定性建议

为维持产品活性，需遵循以下储存规范：

• 短期使用（1-2周）：4℃避光保存（避免反复开盖）；
• 中期储存（≤12个月）：-20℃避光保存（需置于密封容器内）；
• 长期储存（>12个月）：-80℃避光保存（建议分装后储存，减少冻融次数）；
• 关键注意事项：严格禁止反复冻融循环，否则可能导致蛋白构象改变及活性下降。

注意：以上信息可能随着产品优化升级等因素产生变动，具体信息请咨询亚科因公司。

BioSIM Human Bispecific gp100 peptide & HLA-A*02:01 (Tebentafusp Biosimilar), Research Grade

I. Core Product Information

• Full English Name: BioSIM Human Bispecific gp100 peptide & HLA-A*02:01 (Tebentafusp Biosimilar), Research Grade
• Full Chinese Name: BioSIM 人双特异性gp100肽&HLA-A*02:01（特本塔夫斯普/替本福司）生物类似药 科研用途
• CAS Number: 1874157-95-5
• Product Number: SIM0736-5mg
• Product Type: Recombinant Protein
• Specification: 5mg/vial
• Supplier: InvivoCrown

II. Production Background and Process Characteristics

This product is a recombinant biosimilar of Tebentafusp, produced in strict accordance with research-grade product standards:

• Production Environment: Animal-Free Facility, avoiding potential interference of animal-derived contaminants on experimental results;
• Expression System: Mammalian Cell Expression, ensuring natural protein folding and activity;
• Cultivation Process: Protein-Free Cell Culture Technology, reducing the impact of impure proteins on purification and subsequent experiments;
• Purification Process: Multi-step Chromatography Purification (including Protein A/G affinity chromatography), enhancing product purity and uniformity.

III. Research Applications

This product is for research use only, primarily suitable for the following fields:

• Research on the pathogenesis of melanoma;
• Research on the mechanism of targeted therapy for uveal melanoma (eye cancer);
• Tumor immunity research related to immune checkpoints.

IV. Buffer System Details

The product is dissolved in the following stable buffer:

• 9 mM Citric acid monohydrate;
• 41 mM Disodium hydrogen phosphate (Na₂HPO₄);
• 1% Mannitol;
• 5% Trehalose;
• 0.02% Tween 20;
• 2 mM Dithiothreitol (DTT);
• pH: 6.5 (at 25°C).

V. Storage and Stability Recommendations

To maintain product activity, the following storage guidelines should be followed:

• Short-term use (1-2 weeks): Store at 4°C protected from light (avoid repeated opening);
• Medium-term storage (≤12 months): Store at -20°C protected from light (must be placed in a sealed container);
• Long-term storage (>12 months): Store at -80°C protected from light (it is recommended to store in aliquots to reduce freeze-thaw cycles);
• Key Notes: Strictly prohibit repeated freeze-thaw cycles, as this may lead to protein conformational changes and decreased activity.

Note: The above information may change due to factors such as product optimization and upgrades. For specific information, please consult Yakeyin Biotechnology.