ab18599-500ug，HRP Anti-Protein

Protein G also known as IgG-binding protein is a cell wall protein from Streptococcus species. This protein weighs approximately 22 kDa which you might also know as protein G molecular weight (protein G MW). Protein G size allows it to bind specifically to immunoglobulin G (IgG) and other subclasses. Researchers often clone and express protein G recombinantly resulting in wide availability of recombinant protein G. Its expression primarily occurs in bacterial cell cultures for easy purification and use in laboratory research./ Biological function summary/ Protein G plays a role in immune evasion by binding to the Fc region of IgG antibodies. This binding limits the immune system's ability to clear bacterial infections by preventing antibody-mediated opsonization and phagocytosis. Protein G can also form part of a larger immobilization complex in various experimental setups aiding in the purification and detection of antibodies. Protein G HRP conjugates further extend its utility in assay systems by enabling colorimetric detection./ Pathways/ The interaction between protein G and IgG significantly impacts the immune response pathways. The binding of protein G to the Fc region of IgG interferes with pathways involving IgG-mediated activation of Fc receptors on immune cells. This affects signaling pathways like ADCC (antibody-dependent cellular cytotoxicity) and phagocytosis. Protein A is another bacterial protein that binds IgG similarly though it differs in affinity and subclass specificity./