ab18123-50ug，Anti-ATF1 - S.pom

ATF1 also known as Activating Transcription Factor 1 is a transcription factor in Schizosaccharomyces pombe (S. pombe). ATF1 has a mass of approximately 45 kDa and is expressed in the nucleus. It works as a DNA-binding protein that regulates gene expression by binding to cAMP response elements. ATF1's activity depends on phosphorylation which modulates its function during cellular stress responses./ Biological function summary ATF1 in S. pombe plays an essential role in stress responses and cell cycle regulation. It acts not as an isolated unit but as part of a transcriptional activation complex with Pcr1. This complex formation allows ATF1 to regulate various genes involved in responses to oxidative stress and osmotic stress ensuring cell survival under adverse conditions. Its activation can lead to the expression of genes needed for cell adaptation and maintenance./ Pathways/ ATF1 is heavily involved in the stress-activated protein kinase (SAPK) signaling pathway. In this pathway ATF1 interacts with proteins such as Sty1 which phosphorylates ATF1 promoting its activity. This interaction is an important link in the cascade that enables cellular adaptation to environmental changes. The SAPK pathway illustrates ATF1’s involvement in regulating gene expression responses that ensure proper cellular reaction to stress stimuli./