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- ab15697-100ug
- 2025年11月01日
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
Anti-IRSp53 antibody - C-terminal
- 应用范围：
仅用科研
- 保质期：
见瓶身
- 库存：
99
- 供应商：
嘉兴亦高
- 保存条件：
-20°
- 规格：
100ug
IRSp53 also known as BAIAP2 (Brain-Specific Angiogenesis Inhibitor 1-Associated Protein 2) is a protein with a molecular mass of approximately 58 kDa. It acts as an important regulator of actin cytoskeleton dynamics facilitating the formation of membrane protrusions like filopodia and lamellipodia. IRSp53 is expressed ubiquitously in various tissues with higher levels observed in the brain. It contains several domains including the IMD (I-BAR) domain which is involved in membrane curvature and actin binding./
Biological function summary/
IRSp53 participates in the modulation of cell shape and motility. It is a component of the protein complexes that couple membrane dynamics to cytoskeleton remodeling. Through its interaction with proteins like CDC42 and Rac1 IRSp53 guides the rearrangement of actin filaments affecting cell movement and shape. These abilities make it significant for cellular processes requiring changes in cell structure such as neurodevelopment and wound healing./
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文献和实验该产品被引用文献
eLife 9: | PubMed 32975518
2020
Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme.
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Applications
Unspecified application
Species
Unspecified reactive species
Roman O Fedoryshchak, Magdalena Přechová, Abbey M Butler, Rebecca Lee, Nicola O'Reilly, Helen R Flynn, Ambrosius P Snijders, Noreen Eder, Sila Ultanir, Stephane Mouilleron, Richard Treisman
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ab15697-100ug，Anti-IRSp53 antibody - C-terminal
￥3215
