ab14460-100ug，Anti-Poly (ADP-R

Poly (ADP-Ribose) Polymerase often abbreviated as PARP is an enzyme that plays an important role in cellular processes. PARP catalyzes the addition of ADP-ribose units from NAD+ to target proteins—a process known as poly(ADP-ribosyl)ation. This modification is important for modulating protein function. The enzyme has a molecular weight of approximately 116 kDa. PARP is located mainly in the nucleus of cells and shows high expression in tissues with elevated cellular proliferation and metabolism such as the brain and testis./ Biological function summary/ PARP is integral to the DNA damage response mechanism in eukaryotic cells. It detects and signals single-strand DNA breaks inducing repair by recruiting DNA repair complexes. PARP collaborates with XRCC1 to facilitate the base excision repair pathway. As a part of these complexes PARP’s activity ensures cell survival under stress conditions. In concert with other poly (ADP-ribose) molecules PARP also influences chromatin structure impacting gene expression./