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ab16728-500ul,Anti-CD44 antibo

dy [156-3C11]
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  • ¥3473
  • Abcam
  • ab16728-500ul
  • 2025年11月01日
  • 仅用科研
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 抗体名

      Anti-CD44 antibody [156-3C11]

    • 应用范围

      仅用科研

    • 保质期

      见瓶身

    • 库存

      99

    • 供应商

      嘉兴亦高

    • 保存条件

      -20°

    • 规格

      500ul

    The protein expressed by gene CD44 functions as a cell-surface receptor involved in cell-cell interactions, cell adhesion, and migration, allowing cells to detect and react to changes in their tissue microenvironment. It is implicated in numerous cellular processes, including the activation, recirculation, and homing of T-lymphocytes, hematopoiesis, inflammation, and the response to bacterial infection. Through its ectodomain, CD44 interacts with extracellular matrix components like hyaluronan, collagen, growth factors, cytokines, and proteases, serving as a platform for signal transduction by forming protein complexes with receptor kinases and membrane proteases via its cytoplasmic domain. Effectors such as PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases, and phospholipase C coordinate signaling pathways that promote calcium mobilization and actin-mediated cytoskeleton reorganization crucial for cell migration and adhesion. This supplementary information is collated from multiple sources and compiled automatically.

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    图标文献和实验
    该产品被引用文献
    Frontiers in medicine 9:697443 | PubMed 35223886 2022 Glucocorticoids Inhibit EGFR Signaling Activation in Podocytes in Anti-GBM Crescentic Glomerulonephritis. out Applications Unspecified application Species Unspecified reactive species Xiaomei Wu, Lu Ren, Qianqian Yang, Hui Song, Qiaoli Tang, Mingchao Zhang, Jiong Zhang, Zheng Tang, Shaolin Shi
    相关实验
    • Protocol for anti-HA antibody Western Blotting

      film for ~2 mins. Notes on the primary antibody: Source : Covance/Babco Description: Crude ascites fluid monoclonal anti-HA antibody (CATLN#135032002, 11mms-101R, 0.5 ml) Handling: Aliquoted into 10ul portions in -20℃ Internal notes: labelled anti

    • Antibody Purification

      Blue Regeneration Buffer 2 M guanidine HCl or 1.5 M Na thiocyanate HiTrap Storage Buffer 10 mM Tris 7.5 1 ml 1M Tris 7.5 0.1 mM EDTA 20 ul 500 mM EDTA 50 mM NaCl 1 ml 5M NaCl 0.1% azide 0.1 g Na azide up to 100

    • Antibody Staining of Dissected Gonads

      at least 4 hr at RT or overnight at 4 oC (Overnight at 4 oC is probably best).   *Wash in PBTw,  3-4 x 5 min *Wash in PBS containing 100 ng/ml DAPI. *Wash in PBTw, once *Place in 80% glycerol containing anti-fade reagent (e.g., Dapco) about 20 ­ 30 ul

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    文献支持
    ab16728-500ul,Anti-CD44 antibody [156-3C11]
    ¥3473