ab11137-50ul，Anti-ProDynorphin

Dynorphin B often referred to as Big Dynorphin is an opioid peptide that belongs to the endorphin family. This peptide is derived from the precursor protein prodynorphin also known by the gene symbol PDYN. Dynorphin B typically has a mass of around 3.4 kDa. It expresses mainly in the central nervous system particularly within the hypothalamus hippocampus and spinal cord. These locations correspond to its function as a modulator of neural activity often influencing pain perception and stress response./ Biological function summary/ Dynorphin B acts as a neurotransmitter and neuromodulator. It binds to the kappa-opioid receptor forming a complex that modulates synaptic transmission. Dynorphin B influences several neurological processes including the regulation of dopamine levels and the modulation of pain pathways. Given its role in neural signaling dynorphin B is involved in regulating the body's response to stress and addiction mechanisms./ Pathways/ The activity of dynorphin B integrates primarily within the nociceptive pathway and stress-related pathways. The peptide's interaction with the kappa-opioid receptor significantly influences these pathways. It's related to other opioid peptides such as beta-endorphin and enkephalins. These interactions affect the release of neurotransmitters and consequent biological responses which are important in the body's adaptation to stress and perception of pain./