FLT3 kinase inhibitor 2HCl;241

Kinase Inhibitor Profiling Using Chemoproteomics

Quantitative chemoproteomics has recently emerged as an experimental approach to determine protein interaction profiles of small molecules in a given cell line or tissue. In contrast to standard biochemical and biophysical kinase assays

Kinase Inhibitor Selectivity Profiling Using Differential Scanning Fluorimetry

and widely used approach is the direct measurement of the effect of the added ligands on its activity. A variety of enzymatic assay formats have been successfully applied for inhibitor screening of protein kinases. However, enzymatic assays require an active

FLT3 Mutations in Acute Myeloid Leukemia

The prevalence of an internal tandem duplication (ITD) of the juxtamembrane domain-coding sequence and a missense mutation of D835 within the kinase domain of the FLT3 gene is 15–35% and 5–10% of adults with acute myeloid leukemia (AML