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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20℃
- 库存:
99
- 供应商:
上海源叶生物科技有限公司
- CAS号:
237402-29-8
- 规格:
1mg
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文献和实验The mammalian target of rapamycin (mTOR) is the catalytic subunit of two multiprotein complexes, mTOR complex-1 (mTORC1) and mTOR complex-2 (mTORC2). Clinically used rapamycin and rapalogs are FKBP12-dependent allosteric inhibitors of mTORC
Evaluating the Therapeutic Potential of mTOR Inhibitors Using Mouse Genetics
effector of PI3K signaling, one of the most frequently activated pathways in cancer. In cells, mTOR is the catalytic core subunit of two distinct complexes, mTORC1 and mTORC2, which are defined by unique mTOR-interacting proteins and have unique functions
294002 competitively inhibits ATP binding to the catalytic subunit of PI 3-kinases and does not inhibit PI 4-kinase, DAG-kinase, PKC, PKA, MAPK, S6 kinase, EGFR or c-src tyrosine kinases and rabbit kidney ATPase. lxj46 信号通路的激活大多通过磷酸化状态
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