Sample:
HUVEC(Human) Cell Lysate at 30 ug
Primary: Anti- Nectin 3 (bs-6181R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
- ￥1180 - 2800
- Bioss
- bs-6181R
- 2025年10月25日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6181R |
| 英文名称 | Nectin 3 Rabbit pAb |
| 中文名称 | 连接蛋白3抗体 |
| 英文别名 | CD113; CDw113; DKFZP566B0846; FLJ90624; Nectin-3; Nectin3; Poliovirus receptor related 3; Poliovirus receptor related protein 3; Poliovirus receptor-related protein 3; PPR3; PRR3; PVRL 3; PVRL3; PVRL3_HUMAN; PVRR3. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Cow, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Nectin 3 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 55 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors Microbiology > Interspecies Interaction > Host Virus Interaction |
| 亚基 | Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT. |
| 亚细胞定位 | Cell membrane; Single-pass membrane protein (Potential). |
| 组织特异性 | Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines. |
| 相似性 | Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nectins are immunoglobulin-like adhesion molecules that interact with afadin. Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin-catenin system in epithelial cells.The nectin/PRR-family consists of four members, nectin-1, -2, -3 and -4. All the members of the nectin family have two or three slice variants. Nectin 3 is mainly expressed in testis and placental tissues and interacts in vivo with both long and short isoforms of afadin. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
Epididymis (Mouse) Lysate at 40 ug
Primary: Anti- Nectin 3 (bs-6181R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
Epididymis (Mouse) Lysate at 40 ug
Primary: Anti- Nectin 3 (bs-6181R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
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文献和实验该产品被引用文献
[IF={{ 4.6 }}] {Qi Wan. et al. Astragalus Polysaccharide Alleviates Ulcerative Colitis by Regulating the Balance of mTh17/mTreg Cells through TIGIT/CD155 Signaling. MOLECULES. 2024 Jan;29(1):241} {WB,IF} {Mouse}
[IF={{ 3.77 }}] {Sheldon R. Gordon. et al. Evidence that Nectin-3 is the soybean agglutinin binding protein on rat corneal endothelium cell surfaces. EXP EYE RES. 2022 Oct;223:109212} {ICC} {Rat}
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Nectin 3 Rabbit pAb(bs-6181R)-50ul/100ul/200ul
￥1180 - 2800
