- ￥99 - 999
- Sigma
- 进口
- Z4152-10MG
- 2025年10月29日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
RT
- 保质期：
见标签
- 库存：
999
- 供应商：
鹿森生物
- CAS号：
107753-78-6
- 规格：
10MG
应用
Zafirlukast has been used to stimulate pancreatic β cell line (MIN6) and pancreatic islets for insulin secretion assay.[1] It may be used as an adenosine triphosphate-binding cassette transporter (ABCG2) inhibitor in MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cytotoxicity assay in human embryonic kidney cells (HEK293)[2] and in Kirby-Bauer disc diffusion assays, bactericidal activity and minimal inhibitory concentration (mIC) assay against M. smegmatis[3]
生化/生理作用
Zafirlukast is a potent subtype specific CysLT1 receptor antagonist; antiasthmatic.
Zafirlukast is a potent subtype specific cysteinyl leukotriene type 1 receptor (CysLT1) antagonist; antiasthmatic. Zafirlukast has over 1000-fold selectivity for CysLT1, one of two receptors for cysteinyl leukotrienes LTC4, LTD4, and LTE4, which are important mediators of human bronchial asthma.
Zafirlukast plays a key role in alleviating mucus and airway constriction in asthma based inflammatory response.[1] It regulates pancreatic β cells for the secretion of insulin and this functionality is interlinked to the calcium based phosphorylation of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and protein kinase B (AKT).[1] Zafirlukast has inhibitory potential on ATP-binding cassette (ABC) transporters and reverses the multidrug resistance function of ATP-binding cassette super-family G member 2 (ABCG2).[2] Zafirlukast inhibits mycobacterial nucleoid-associated protein Lsr2 and halts the growth of Mycobacteria.
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文献和实验for storing and describing biomolecular interactions, molecular complexes and pathways. Bioinformatics, 16(5):465-77. 11• Baldi P and Brunak S.2001.Bioinformatics: the Machine Learning Approach.MIT Press. 12• Bar-Joseph Z, Gerber G, Simon I, Gifford DK
-hybridization wash (50% formamide/2X SSC): To make 500 ml, take 250 ml formamide, add 50 ml 20X SSC stock and complete to 500 ml with DDW. 3. Probe competitor solution (ssDNA/tRNA): To make 100 µl of 10 mg/ml total concentration competitor, take 50 µl of 10mg
µl of 10mg/ml sheared salmon sperm DNA and add 50 µl 10mg/ml E. coli tRNA (prepared from solid by adding 10 mg to 1.0 ml DDW). Store at �20°C. 4. Hybridization buffer: To make 100 µl, take 60 µL DDW and add 20 µL BSA, and 20 µL 20X SSC
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