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Nogo R Rabbit pAb(bs-0129R)-50

ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-0129R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0129R
    英文名称Nogo R Rabbit pAb
    中文名称轴索过度生长抑制因子受体/Nogo受体抗体
    英文别名NgR; Nogo-66 receptor; Nogor; NogoR; Nogo-R; Reticulon 4 receptor; Rtn4r; RTN4R_RAT.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse, Rat
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from mouse Nogo R
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量48 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins

    Neuroscience > Neurology process > Neurodegenerative disease

    Neuroscience > Neurology process > Neurogenesis

    亚基Homomultimer. Interacts with LINGO1. Interacts with KIAA0319L.
    亚细胞定位Cell membrane; Lipid-anchor, GPI-anchor.
    相似性Belongs to the Nogo receptor family.
    Contains 8 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    功能Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity).
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    Brain (Mouse) Lysate at 40 ug
    Primary: Anti- Nogo R (bs-0129R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 48 kD
    Observed band size: 48 kD
    产品细节图片2
    Sample:
    Hippocampus (Mouse) Lysate at 40 ug
    Primary: Anti- Nogo R (bs-0129R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 48 kD
    Observed band size: 48 kD
    产品细节图片3
    Sample:
    Brain (Rat) Lysate at 40 ug
    Primary: Anti- Nogo R (bs-0129R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 48 kD
    Observed band size: 48 kD
    产品细节图片4
    Sample:
    Hippocampus (Rat) Lysate at 40 ug
    Primary: Anti- Nogo R (bs-0129R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 48 kD
    Observed band size: 48 kD
    产品细节图片5
    Tissue/cell: rat brain tissue; 4% P‌‌araformaldehyde-fixed and paraffin-embedded;
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
    Incubation: Anti-Nogo-R Polyclonal Antibody, Unconjugated(bs-0129R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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    该产品被引用文献

    [IF={{ 3.216 }}] {Jing Wanget al. Tanshinone IIA Promotes Axonal Regeneration in Rats with Focal Cerebral Ischemia Through the Inhibition of Nogo-A/NgR1/RhoA/ROCKII/MLC Signaling. Drug Des Devel Ther . 2020 Jul 15;14:2775-2787.} {WB} {rat}

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    Nogo R Rabbit pAb(bs-0129R)-50ul/100ul/200ul
    ￥1180 - 2800