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- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2987R |
| 英文名称 | Vitamin D Receptor Rabbit pAb |
| 中文名称 | 维生素D3受体抗体 |
| 英文别名 | Vitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 1 antibody 1, 25-@dihydroxyvitamin D3 receptor; 125 dihydroxyvitamin D3 receptor; 25-dihydroxyvitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; VDR_HUMAN; Vitamin D(1, 25-dihydroxyvitamin D3) receptor; Vitamin D hormone receptor; Vitamin D receptor; Vitamin D3 receptor, |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC/IF=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Rat (Mouse, Chicken, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Vitamin D Receptor |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 47 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > Nuclear signaling > Nuclear hormone receptors Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Vitamin D Receptor Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Signal Transduction > Signaling Pathway > Nuclear Signaling > Nuclear Hormone Receptors > Vitamin D Receptor |
| 亚基 | Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain. |
| 功能 | Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone ensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {ICC/IF} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 6.575 }}] {Natalia Łabędź. et al. Modulation of Fibroblast Activity via Vitamin D3 Is Dependent on Tumor Type—Studies on Mouse Mammary Gland Cancer. CANCERS. 2022 Jan;14(19):4585} {IF} {Mouse}
[IF={{ 4.6 }}] {Stachowicz-Suhs Martyna. et al. Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines. SCI REP-UK. 2024 Feb;14(1):1-20} {WB} {Human}
[IF={{ 4.285 }}] {Stenhouse Claire. et al. Effects of progesterone and interferon tau on ovine endometrial phosphate, calcium, and vitamin D signaling. Biol Reprod. 2022 Feb;:} {IHC} {Sheep（Ewe）}
[IF={{ 4.095 }}] {Jeremy M et al. Vitamin D3 mediated regulation of steroidogenesis mitigates testicular activity in an aged rat model.J Steroid Biochem Mol Biol. 2019 Jun;190:64-75.} {WB} {Rat}
[IF={{ 3.418 }}] {Guo Y et al. Calcitriol attenuates renal tubular epithelial cells apoptosis via inhibiting p38MAPK signaling in diabetic nephropathy. Acta Diabetol . 2020 Nov;57(11):1327-1335.} {IHC} {Rat}
and heterodimeric complexes that bind with high affinity to their cognate DNA-responsive elements. Following receptor-response element binding, the DNA-bound homodimers and heterodimers must ultimately communicate with the preinitiation complex to influence RNA
Human vitamin D receptor (hVDR) belongs to the superfamily of steroid receptors. The receptors are nuclear transcription factors that regulate gene expression in response to binding of their specific ligands. According to present knowledge
Characterization of CGRP Receptor Binding
., Hay, D.L., Legon, S., Poyner, D.R., Hagner, S., Bloom, S.R., and Smith D.M. 2002. Comparison of the expression of calcitonin receptor‐like receptor (CL) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines
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