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- D1413-10MG
- 2026年01月29日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
RT
- 保质期：
见标签
- 库存：
999
- 供应商：
联硕生物
- CAS号：
3056-17-5
- 规格：
10MG
Application
2′,3′-Didehydro-3′-deoxythymidine has been used in cell treatment.[1] It has also been used as a drug in Caenorhabditis elegans to study drug induced mitochondrial toxicity.[2] It has also been used in the preclinical evaluation of GS-9160.[3]
Biochem/physiol Actions
2′,3′-Didehydro-3′-deoxythymidine is a nucleoside analog, which inhibits HIV replication in vitro. Stavudine has the ability to enter the cells by non-facilitated diffusion. It possesses inhibitory activity against moloney murine leukemia virus, friend murine leukemia virus and simian immunodeficiency virus.[4]
General description
2′,3′-Didehydro-3′-deoxythymidine (d4T), a pyrimidine analogue is the inhibitor of reverse transcriptase.
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文献和实验缩写为 cGMp。分 2′， 3′－ cGMP和 3′， 5′ -cGMP二种。前者为 RNA的酶催化分解的产物，后者在生理上具有重要作用。 3′， 5′ -cGMP是 D． F． Ashman等（ 1963）在鼠尿中发现的。在动物的各种组织中广泛存在，在大肠杆菌中也有发现，在小脑和肺中含量最高。与 3′， 5′－ cAMP一样，能将从细胞外来的刺激向细胞内传递，起所谓的第二信使作用。在鸟苷酸环化酶（ guanylate cyclase）的作用下，由 GTA生成。可由特异的磷酸
ribonucleoside 2′‐conjugates S.11 a‐d and of the 5′‐pyrenylated 2′‐deoxythymidine conjugate S.12 . Abbreviations: B, a uracil‐1‐yl, b cytosin‐1‐yl, c adenin‐9‐yl, d guanin‐9‐yl; Thy, thymin‐1‐yl. Adapted from Cieślak et al. () by permission of Oxford University
Analysis of Bases, Nucleosides, and (Oligo)nucleotides by Capillary Electrophoresis
(Chapter 13 ) and in recent reviews (1 –3 ). A number of nucleosides and nucleotides have been used in chemotherapy as antiviral agents, e.g., 3′-azido-3′-deoxythymidine (azT), and 2′,3′-dideoxyinosine (ddI), and 2′,3′-dideoxycytidine (ddC
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