- ￥99 - 999
- Sigma
- 进口
- A0233-25MG
- 2025年11月05日
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- 详细信息
- 技术资料
- 保存条件：
RT
- 保质期：
见标签
- 库存：
999
- 供应商：
联硕生物
- CAS号：
648450-29-7
- 规格：
25MG
应用
AS605240 has been used:
as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles.[1]
as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction.[2]
as a class 1A PI3K inhibitor to treat CD4+ T cells.[3]
生化/生理作用
AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP).[4] It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R).[5] It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs.[4]
AS605240 is a potent and selective PI3Kγ inhibitor.
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